Research RP -HPLC determination of glaucocalyxin A in rat plasma and its pharmacokinetic and excretion
文献类型：期刊论文
| 作者 | Cao Luhua1; Chen Zijun3; Li Yunsen2; Li Yikui3; Ma Yueming3; Jin Ruomin3 |
| 刊名 | Chinese Journal of Pharmaceutical Analysis
 |
| 出版日期 | 2006 |
| 卷号 | 26期号:11页码:1535-1538 |
| 关键词 | glaucocalyxin A RP - HPLC pharmacokinetic |
| ISSN号 | 0254-1793 |
| 其他题名 | RP-HPLC法测定大鼠血浆中蓝萼甲素含量与药代动力学及排泄研究 |
| 文献子类 | Article |
| 英文摘要 | Objective： To study the phannacokinetic and excretion of glaucocalyxin A in rat and establish the HPLC method in rat plasma, bile, urine and feces. Method：A validated HPLC method was described for the determination of glaucocalyxin A in rat plasma ,bile, urine and feces using a liquid -liquid extraction and UV absorbance detection. Results：The extraction recovery of glaucocalyxin A ranged from 79. 11% to 82. 22%. The linear range was 0. 2 -10 mug · mL~(-1) ,correlation coefficient r =0. 9996. Glaucocalyxin A pharmacokinetic application with iv in rats revealed that glaucocalyxin A followed two -compartment open model, t_(1/2alpha) and t_(1/2alpha)were 4. 32 min and 28.56 min, respectively. The excretion of the parent drug amounted to 23.8% of the dosage within 12 h in feces and the excretion in urine to 12. 8% within 12 h. The bile excretion of glaucocalyxin A amounted to 35.68% of the dosage within 10 h. Conclusion： The method developed is successfully applied to a simple, rapid, specific and accurate HPLC method for investigation of the pharmacokinetics of glaucocalyxin A in rat. |
| 资助项目 | 国家科技部863计划[00000000] ; 新药博士基金资助课题[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2670246 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268276]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Chemical Engineering and Pharmaceutics College of Guangdong, Guangzhou, Guangdong 510520, China.; 2.Shanghai Institute of Materia Medica, Shanghai 201203, China. 3.Institute of Traditional Herb, Shanghai University of Chinese Traditional Medicine, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Cao Luhua,Chen Zijun,Li Yunsen,et al. Research RP -HPLC determination of glaucocalyxin A in rat plasma and its pharmacokinetic and excretion[J]. Chinese Journal of Pharmaceutical Analysis,2006,26(11):1535-1538. |
| APA | Cao Luhua,Chen Zijun,Li Yunsen,Li Yikui,Ma Yueming,&Jin Ruomin.(2006).Research RP -HPLC determination of glaucocalyxin A in rat plasma and its pharmacokinetic and excretion.Chinese Journal of Pharmaceutical Analysis,26(11),1535-1538. |
| MLA | Cao Luhua,et al."Research RP -HPLC determination of glaucocalyxin A in rat plasma and its pharmacokinetic and excretion".Chinese Journal of Pharmaceutical Analysis 26.11(2006):1535-1538. |
入库方式： OAI收割
来源：上海药物研究所
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