Improved synthesis of 2-en-1-one moiety in the A ring of territrem B analogues and evaluation of their protective effect against brain ischemia injury
文献类型：期刊论文
| 作者 | Zhao Jingao1; Zhao Feng1; Li Haibo1; Wu Xiumei5; Wang Panyan2; Jiang Hualiang3 ; Diao Yu4
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2005 |
| 卷号 | 15期号:1页码:1-4 |
| 关键词 | medicinal chemistry preparation chemical synthesis territrem B analogues 2-en-l-one moiety protective effect against OGD-induced injury |
| ISSN号 | 1005-0108 |
| 其他题名 | 土震素B类似物中A环2-烯-1-酮结构的合成方法改进及衍生物抗脑缺血活性 |
| 文献子类 | Article |
| 英文摘要 | Aim To improve the synthetic procedure of 2-en-l-one moiety in the A ring of territrem B ana-logues, and to evaluate their protective activities against OGD (oxygen-glucose deprivation)-induced injury of a primarily cultured newborn rat's hippocampal neurons. Methods The target compounds were synthesized from 2-en-ebester 5 and partially transformed from the by-product of 2-en-l-bromo-ebester 8 via bromina-tion, hydrolysis and oxidation. Their protective activities against injury of a primarily cultured newborn rat's hippocampal neurons arising from OGD were determined. Results and conclusions Four derivatives of 2-en-1-one-ebester 6a~6d were synthesized with the structures confirmed by their H-NMR and MS spectra. The pharmacological data shows that compound 6b is active against injury arising from OGD. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1881207 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268302]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310031, China.; 2.Department ofChemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China.; 3.Shanghai Institute ofMateria Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 4.Department of Traditional Chinese Medicine and Natural Drug Research, College ofPharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310031, China. 5.Zhejiang Hisun Naturelite Pharmaceutical R&D Co .,Ltd, Hangzhou, Zhejiang 310007, China.; |
| 推荐引用方式 GB/T 7714 | Zhao Jingao,Zhao Feng,Li Haibo,et al. Improved synthesis of 2-en-1-one moiety in the A ring of territrem B analogues and evaluation of their protective effect against brain ischemia injury[J]. Chinese Journal of Medicinal Chemistry,2005,15(1):1-4. |
| APA | Zhao Jingao.,Zhao Feng.,Li Haibo.,Wu Xiumei.,Wang Panyan.,...&Diao Yu.(2005).Improved synthesis of 2-en-1-one moiety in the A ring of territrem B analogues and evaluation of their protective effect against brain ischemia injury.Chinese Journal of Medicinal Chemistry,15(1),1-4. |
| MLA | Zhao Jingao,et al."Improved synthesis of 2-en-1-one moiety in the A ring of territrem B analogues and evaluation of their protective effect against brain ischemia injury".Chinese Journal of Medicinal Chemistry 15.1(2005):1-4. |
入库方式： OAI收割
来源：上海药物研究所
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