Pharmacokinetics of zero-order release and first-order release of mono-compartment drugs administered by non-parenteral route
文献类型：期刊论文
| 作者 | Zhang Jiwen2 ; Zhong Dafang1; Bi Dianzhou1
|
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2005 |
| 卷号 | 21期号:2页码:245-248 |
| 关键词 | zero-order release first-order release mono-compartment pharmacokinetics sustained re-lease controlled release |
| ISSN号 | 1001-1978 |
| 其他题名 | 单室模型药物血管外给药零级、一级释放药物动力学 |
| 文献子类 | Article |
| 英文摘要 | Aim To establish the pharmacokinetic principles of the zero-order release and the first-order release of mono-compartment drugs administered by non-parenteral route based on the release kinetics of the dosage forms and the intrinsic pharmacokinetic pa-rameters of the active drug, such as the rate constants of the absorption and elimination, and the distribution volume of the drug. Methods By the Laplace trans-form and the compartmental analysis method, the phar-macokinetic behaviors of the zero-order release and the first-order release of mono-compartment drugs adminis-tered by non-parenteral routes were deduced with divi-sions of the dose being absorbed during the release phase and after the release has terminated. Results The pharmacokinetics of the non-parenteral administra-tion of the zero-order release and the first-order release of mono-compartment drugs were established. Conclu-sion The pharmacokinetic theories of the zero-order release and the first-order release of mono-compartment drugs administered by non-parenteral route have been established. Since the zero-order release and the first-order release are the primary release patterns, the the-ory should be a key to explore the pharmacokinetics of the controlled/sustained release dosage forms. |
| WOS研究方向 | General & Internal Medicine ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1928497 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268308]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shenyang Pharmaceutical University, Shenyang, Liaoning 110015, China. 2.Shanghai Institute ofMeteria Medica, Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Zhang Jiwen,Zhong Dafang,Bi Dianzhou. Pharmacokinetics of zero-order release and first-order release of mono-compartment drugs administered by non-parenteral route[J]. Chinese Pharmacological Bulletin,2005,21(2):245-248. |
| APA | Zhang Jiwen,Zhong Dafang,&Bi Dianzhou.(2005).Pharmacokinetics of zero-order release and first-order release of mono-compartment drugs administered by non-parenteral route.Chinese Pharmacological Bulletin,21(2),245-248. |
| MLA | Zhang Jiwen,et al."Pharmacokinetics of zero-order release and first-order release of mono-compartment drugs administered by non-parenteral route".Chinese Pharmacological Bulletin 21.2(2005):245-248. |
入库方式： OAI收割
来源：上海药物研究所
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