Progress in the preparation of siRNAs
文献类型：期刊论文
| 作者 | Zhang Zhonghua; Hou Yongtai |
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2004 |
| 卷号 | 16期号:4页码:231 |
| 关键词 | siRNA shRNA siRNA preparation siRNA shRNA RNA interference |
| ISSN号 | 1004-0374 |
| 其他题名 | siRNA制备技术的研究进展 |
| 文献子类 | Article |
| 英文摘要 | Recently, siRNAs (small interfering RNAs) have been widely used to induce RNA interference in mammalian systems. Till now, there are five methods to produce siRNAs, such as chemical synthesis, in vitro transcriptions, RNase Ill-family enzymatic digestion, siRNA expression vectors and siRNA expression cassettes. It is essential to choose an effective siRNA sequence in those methods. Furthermore, with the developments of drug discovery and genomics, the siRNAs preparation should be developed and consummated in several ways, such as high-throughput screening of effective siRNAs, stability of siRNAs, efficiently gene transfer and regulation of the expression of siRNAs.` |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1605867 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268407]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Zhonghua,Hou Yongtai. Progress in the preparation of siRNAs[J]. Chinese Bulletin of Life Sciences,2004,16(4):231. |
| APA | Zhang Zhonghua,&Hou Yongtai.(2004).Progress in the preparation of siRNAs.Chinese Bulletin of Life Sciences,16(4),231. |
| MLA | Zhang Zhonghua,et al."Progress in the preparation of siRNAs".Chinese Bulletin of Life Sciences 16.4(2004):231. |
入库方式： OAI收割
来源：上海药物研究所
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