Relationship Between Angiogenensis and Drug Resistance in the Drug Resistant Gastric Cancer Xenograft of Nude Mice
文献类型：期刊论文
| 作者 | Chen Ying; Wu Yunlin; Lu Lijuan |
| 刊名 | Acta Universitatis Medicinalis Secondae Shanghai
 |
| 出版日期 | 2003 |
| 卷号 | 23期号:6页码:495 |
| 关键词 | gastric cancer drug resistance nude mice vascular |
| ISSN号 | 0258-5898 |
| 其他题名 | 耐药胃癌裸鼠移植瘤中血管生成与耐药机制的关系 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the relationship of angiogenensis and the mechanisms of drug resistance in human gastric drug resistant cancer xenograft of nude mice. Methods Establishing cancer xenograft model in nude mice. The mRNA expression for vascular endothelial growth faclor ( VEGF) was measured by reverse transcription polymerase chain reaction ( RT - PCR ) . The protein expression of VEGF in the xenograft of nude mice was determined by immunohistochemistry. Vascular endothelial cells were stained by immunohistochemistry and intratumoral microvessel density (MVD) was counted. Results The two teams of cancer xenograft of nude mice, the drug resistant and the parent, were successfully estab-lished. Comparing parent cancer xenograft,the mRNA expression and protein expression of VEGF and mi-crovessel density of the drug resistant cancer xenograft were ^significantly decreased (P <0. 05). Conclu-sion The mechanism of drug resistance of gastric cancer may be related with the decreased angiogenesis. |
| 资助项目 | 上海市科技发展基金资助项目（004119048）[00000000] |
| WOS研究方向 | Oncology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1269990 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268422]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Department of Gastroenterology, Ruijin Hospital, SSMU, Shanghai 200025, China. |
| 推荐引用方式 GB/T 7714 | Chen Ying,Wu Yunlin,Lu Lijuan. Relationship Between Angiogenensis and Drug Resistance in the Drug Resistant Gastric Cancer Xenograft of Nude Mice[J]. Acta Universitatis Medicinalis Secondae Shanghai,2003,23(6):495. |
| APA | Chen Ying,Wu Yunlin,&Lu Lijuan.(2003).Relationship Between Angiogenensis and Drug Resistance in the Drug Resistant Gastric Cancer Xenograft of Nude Mice.Acta Universitatis Medicinalis Secondae Shanghai,23(6),495. |
| MLA | Chen Ying,et al."Relationship Between Angiogenensis and Drug Resistance in the Drug Resistant Gastric Cancer Xenograft of Nude Mice".Acta Universitatis Medicinalis Secondae Shanghai 23.6(2003):495. |
入库方式： OAI收割
来源：上海药物研究所
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