Expression of Bax, Bcl-2 and Caspase-3 in hippocampal CA1 region following cerebral ischemia-reperfusion injury
文献类型：期刊论文
| 作者 | Jin Daozhong2; Liu Zhengqing1; Ma Zhijian1; Cai Weijun1; Zhang Zhijun1; Wen Xiaodan1 |
| 刊名 | Chinese Journal of Anatomy
 |
| 出版日期 | 2003 |
| 卷号 | 26期号:1页码:21-25 |
| 关键词 | cerebrum hippocampus cerebral ischemia apoptosis Caspase-3 Kunming mouse |
| ISSN号 | 1001-1633 |
| 其他题名 | 脑缺血再灌注损伤的海马神经元对Bax、Bcl-2和Caspase-3的表达 |
| 文献子类 | Article |
| 英文摘要 | Objective:To explore the expression of apoptosis regulated genes of hippocampus after cerebral ischemia-reper-fusion. Methods: With immunohistochemical method, the immunoreponsive activity of Bax,Bcl-2 and CM1(active form of Caspase-3)were observed in hippocampal CA1 region of Kunming mice following transient bilateral common carotid arteries(BCCA)ligation with 7 min and different reperfusion period(24h,48h,72h,7d,14d group).Results:The number of Bax and CM1 positive neurons was more in 48h than all other ones(P＜0.01).Their expession decreased significantly in 72h group, and could not be detected in 14d group. The number of Bcl-2 positive neurons was increased in 48h group (compared with the 24h group, p＜0.01),which was decreased in 72h group, However, it increased again in 7d group, and reached the peak on 14d. The number of Bax positive neurons was significantly more than the number of Bcl-2 positive neurons in 24h, 48h, 72h, 7d,14d group(p＜0.05).On contrast, it was reverse in 14d group. Conclusion: The expression of Bax and Caspase-3 is increased in early reperfusion period, so does the expression of Bcl-2 in late reperfusion period; and the expression of Bax exceeding Bcl-2 may be associated with the activation of Caspase-3. |
| 资助项目 | 湖南省自然科学基金资助项目（编号：00JJY2069）[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1300680 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268470]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Anatomy, Xiangya Medical College, Central South University, Changsha, Hunan 410078, China. 2.Shanghai Institute of Materia Medical, Chinese Academy of Sciences.; |
| 推荐引用方式 GB/T 7714 | Jin Daozhong,Liu Zhengqing,Ma Zhijian,et al. Expression of Bax, Bcl-2 and Caspase-3 in hippocampal CA1 region following cerebral ischemia-reperfusion injury[J]. Chinese Journal of Anatomy,2003,26(1):21-25. |
| APA | Jin Daozhong,Liu Zhengqing,Ma Zhijian,Cai Weijun,Zhang Zhijun,&Wen Xiaodan.(2003).Expression of Bax, Bcl-2 and Caspase-3 in hippocampal CA1 region following cerebral ischemia-reperfusion injury.Chinese Journal of Anatomy,26(1),21-25. |
| MLA | Jin Daozhong,et al."Expression of Bax, Bcl-2 and Caspase-3 in hippocampal CA1 region following cerebral ischemia-reperfusion injury".Chinese Journal of Anatomy 26.1(2003):21-25. |
入库方式： OAI收割
来源：上海药物研究所
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