Anti-emetic Effect of Ethanol Extract from "Wuzhuyu Broth"
文献类型：期刊论文
| 作者 | Zhang Ting1; Wang Minwei2; Chen Siwei2 |
| 刊名 | China Journal of Chinese Materia Medica
 |
| 出版日期 | 2002 |
| 卷号 | 27期号:11页码:862-866 |
| 关键词 | wu zhuyu broth anti-emesis vomiting |
| ISSN号 | 1001-5302 |
| 其他题名 | 吴茱萸汤醇提各组分止呕活性的研究 |
| 文献子类 | Article |
| 英文摘要 | Objective:To investigate the anti-emetic effect of ethanol extract from " WuZhuYu broth" and its mechanism. Method:Three experiments were carried out test which extract has anti-emetic activity, such as CuSCVinduced pigeon's emetic response, gastric emptying in mice and ACh-induced or 5-HT-induced contraction in vitro gas-tric muscle in rats. Meanwhile, effect of anti-emetic extract on concentration-response curve to ACh, 5-HT, histamine was investigated. Result: 50% ethanol extract and 70% ethanol extract were identified as having significantly stronger anti-emetic activities with little side effect, which showed the significant effect on concentration-response curve to ACh, 5-HT, histamine. Conclusion: 50% ethanol extract and 70% ethanol extract contain more anti-emetic fractions, more anti-emetic fractions can be gained at the concentrations of 50% and 70% ethanol; the mechanism of anti-emetic effect is related to its antago-nism to the receptors of ACh, 5-HT, histamine. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1081889 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268477]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Institute of Masteria Medica, Shanghai 200031, China.; 2.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. |
| 推荐引用方式 GB/T 7714 | Zhang Ting,Wang Minwei,Chen Siwei. Anti-emetic Effect of Ethanol Extract from "Wuzhuyu Broth"[J]. China Journal of Chinese Materia Medica,2002,27(11):862-866. |
| APA | Zhang Ting,Wang Minwei,&Chen Siwei.(2002).Anti-emetic Effect of Ethanol Extract from "Wuzhuyu Broth".China Journal of Chinese Materia Medica,27(11),862-866. |
| MLA | Zhang Ting,et al."Anti-emetic Effect of Ethanol Extract from "Wuzhuyu Broth"".China Journal of Chinese Materia Medica 27.11(2002):862-866. |
入库方式： OAI收割
来源：上海药物研究所
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