The toxicity of beta-amyloid peptide depends on its length in transgenic Drosophila model of Alzheimer′s disease
文献类型：期刊论文
| 作者 | Han Meng; Ma Pingli; Ye Chunyan |
| 刊名 | Chinese Journal of Gerontology
 |
| 出版日期 | 2015 |
| 卷号 | 35期号:5页码:1315-1317 |
| 关键词 | Alzheimer′s disease Transgenic Drosophila beta-amyloid peptides |
| ISSN号 | 1005-9202 |
| 其他题名 | 阿尔茨海默病果蝇模型中Abeta毒性的长度依赖性 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the toxic effects of the beta-amyloid (Abeta) peptide depends on its length in transgenic Drosophila model of Alzheimer′s disease (AD).Methods Using the classic GAL4/UAS system, three groups of transgenic flies expressing Abeta_(40)(Abeta_(40) group), Abeta_(42)(Abeta_(42) group) and Abeta_(43)(Abeta_(43) group) were constructed in neurons respectively. The climbing assay and survival assay were performed on the three groups and control flies.Results Compared with control group, all Abeta-expressing flies showed enhanced age-dependent locomotor decline and shortened lifespan, with the order:control group>Abeta_(40) group>Abeta_(42) group>Abeta_(43) group.Conclusions Expression of Abetain neurons produces toxicity in Drosophila and the toxicity is length-dependent, the longer the higher. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Neurosciences & Neurology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5368961 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269292]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Department of Neurology, Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200233, China. |
| 推荐引用方式 GB/T 7714 | Han Meng,Ma Pingli,Ye Chunyan. The toxicity of beta-amyloid peptide depends on its length in transgenic Drosophila model of Alzheimer′s disease[J]. Chinese Journal of Gerontology,2015,35(5):1315-1317. |
| APA | Han Meng,Ma Pingli,&Ye Chunyan.(2015).The toxicity of beta-amyloid peptide depends on its length in transgenic Drosophila model of Alzheimer′s disease.Chinese Journal of Gerontology,35(5),1315-1317. |
| MLA | Han Meng,et al."The toxicity of beta-amyloid peptide depends on its length in transgenic Drosophila model of Alzheimer′s disease".Chinese Journal of Gerontology 35.5(2015):1315-1317. |
入库方式： OAI收割
来源：上海药物研究所
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