Improvement of Oral Absorption of Probucol by Solid Self-microemulsion
文献类型：期刊论文
| 作者 | Bao Xiaoyue1; Jiang Shijun2; Dan Zhaoling2; Xu Leilei2; Chen Dawei1 |
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2015 |
| 卷号 | 46期号:1页码:27-31 |
| 关键词 | probucol solid self-microemulsion bioavailability |
| ISSN号 | 1001-8255 |
| 其他题名 | 固态自微乳提高普罗布考口服吸收 |
| 文献子类 | Article |
| 英文摘要 | The probucol solid self-microemulsion (1-SSME) with mean particle size of 27 nm was prepared by grinding method. The results of differential scanning calorimetry and X-ray diffraction analyses showed that the drug existed in an amorphous status in the 1-SSME. In 0.1 mol/L hydrochloric acid and pH 6.8 phosphate buffer, the dissolutions at 1 h of 1-SSME were 56% and 66%, respectively. Compared with the bulk drug, the cmax and AUC of 1-SSME in rats were significantly improved. The relative bioavailability of 1-SSME was 350%. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5343690 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269293]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Bao Xiaoyue,Jiang Shijun,Dan Zhaoling,et al. Improvement of Oral Absorption of Probucol by Solid Self-microemulsion[J]. Chinese Journal of Pharmaceuticals,2015,46(1):27-31. |
| APA | Bao Xiaoyue,Jiang Shijun,Dan Zhaoling,Xu Leilei,&Chen Dawei.(2015).Improvement of Oral Absorption of Probucol by Solid Self-microemulsion.Chinese Journal of Pharmaceuticals,46(1),27-31. |
| MLA | Bao Xiaoyue,et al."Improvement of Oral Absorption of Probucol by Solid Self-microemulsion".Chinese Journal of Pharmaceuticals 46.1(2015):27-31. |
入库方式： OAI收割
来源：上海药物研究所
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