Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy
文献类型：期刊论文
| 作者 | Li Ci; Zhao Liangcai; Fang Yiqun; Chen Ruiyong; Liu Yuming; Yuan Hengrong; Li Jun ; Chen Haiting; Lin Donghai; Xiao Weibing
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| 刊名 | Chinese Journal of Nautical Medicine and Hyperbaric Medicine
 |
| 出版日期 | 2014 |
| 卷号 | 21期号:5页码:289 |
| 关键词 | Saturation dive Helium-oxygen Nuclear magnetic resonance Metabonomics |
| ISSN号 | 1009-6906 |
| 其他题名 | 利用~1H核磁共振代谢组学技术研究250m饱和暴露对人体代谢模式的影响 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the effects of 250 m helium-oxygen (heliox) saturation dive on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy. Methods Seven male divers performed the 250 m heliox saturation dive by using the dry diving simulator. Urine morning samples were collected at various stages, before dive, during dive and after dive. Urine spectra were acquired by using the 600 MHz nuclear magnetic resonance (NMR),and then mode identification was performed by SIMCA-P + 12. 0 software. Results Stay at the storage depth, decompression and the whole process of saturation exposure at a pressure of 250 m exerted significant effects on the metabolismof divers. From urine samples, 13 metabolites were screened (P<0.05). They were creatine, creatitine, glucose, citric acid, alpha-ketoglutarate, lactate, acetoacetate, acetate, phenylalanine, isoleucine, N-oxide trimethylamine, dimethylamine and hippuric acid, which could reflect energy metabolism, amino acid metabolism, amine metabolism and kidney function. Conclusions NMR-based metabonomic analysis could provide information on endogenous metabolites which characterized changes in energy supply form induced by the 250 m heliox saturation exposure in the dry chamber. |
| 资助项目 | 解放军总后勤部重点科研计划项目[00000000] ; 总后卫生部面上项目[00000000] ; 海军后勤部科研计划项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5289834 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269308]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Naval Medical Research Institute, Shanghai 200433, China. |
| 推荐引用方式 GB/T 7714 | Li Ci,Zhao Liangcai,Fang Yiqun,et al. Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy[J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine,2014,21(5):289. |
| APA | Li Ci.,Zhao Liangcai.,Fang Yiqun.,Chen Ruiyong.,Liu Yuming.,...&Xiao Weibing.(2014).Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy.Chinese Journal of Nautical Medicine and Hyperbaric Medicine,21(5),289. |
| MLA | Li Ci,et al."Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy".Chinese Journal of Nautical Medicine and Hyperbaric Medicine 21.5(2014):289. |
入库方式： OAI收割
来源：上海药物研究所
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