Alkaloids from lotus leaf and related bioactivities
文献类型：期刊论文
| 作者 | Yuan Pulong1; Chen Liang1; Liu Xiaoyu2; Yu Bangwei3; Haung Qi3; Chen Kaixian1 ; Li Yiming1; Jia Qi1
|
| 刊名 | Chinese Traditional Patent Medicine
 |
| 出版日期 | 2014 |
| 卷号 | 36期号:11页码:2330-2333 |
| 关键词 | lotus leaf(Nelumbo nucifera) alkaloids 2-hydroxy-l-methoxyaporphine antibacterial lipid-lowering hypoglycemic |
| ISSN号 | 1001-1528 |
| 其他题名 | 荷叶生物碱分离及相关活性研究 |
| 文献子类 | Article |
| 英文摘要 | AIM To isolate alkaloids from lotus leaf and study their antimicrobial,hypoglycemic and lipid-lowering activities of the isolated alkaloids. METHODS Column chromatography and spectra analysis were used to separate and identify alkaloids from lotus leaf,broth microdilution method was employed to the antibacterial activity of the compounds on ten kinds of common pathogenic bacteria and fungi,while 4-nitrophenyl acetate and 4nitrophenyl-D-glucopyranoside as substrates were used to measure the inhibitory activity of pancreatic lipase and alpha- glucosidase enzyme,respectively. RESULTS Six alkaloids were isolated from lotus leaf and identified as nuciferine,2-hydroxy-l-methoxyaporphine,liriodenine,lysicamine,nornuciferine and armepavine. Bioassay showed that liriodenine had the same MIC values of 32 mug / mL against Escherichia coli,Bacillus subtilis and Staphylococcus aureus while that for armepavine against Trichophyton rubrum and Microsporum gypseum were 16 mug / mL as well. Under the 300 mumol / L inhibitory level,liriodenine and 2-hydroxy-l-methoxyaporphine on alpha -glucosidase enzyme were 40. 29% 3. 06% and 27. 62% 2. 21%,respectively. CONCLUSIONS 2-hydroxy-l-methoxyaporphine has certain inhibitory activity of alpha -glucosidase enzyme. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5283252 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269309]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Phytochemistry,College of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; 2.Department of Biochemistry,College of Pharmacy,Second Military Medical University, Shanghai 200433, China.; 3.The Third Department of Pharmacology,Shanghai Institute of Materia Medica, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Yuan Pulong,Chen Liang,Liu Xiaoyu,et al. Alkaloids from lotus leaf and related bioactivities[J]. Chinese Traditional Patent Medicine,2014,36(11):2330-2333. |
| APA | Yuan Pulong.,Chen Liang.,Liu Xiaoyu.,Yu Bangwei.,Haung Qi.,...&Jia Qi.(2014).Alkaloids from lotus leaf and related bioactivities.Chinese Traditional Patent Medicine,36(11),2330-2333. |
| MLA | Yuan Pulong,et al."Alkaloids from lotus leaf and related bioactivities".Chinese Traditional Patent Medicine 36.11(2014):2330-2333. |
入库方式： OAI收割
来源：上海药物研究所
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