3Dfine structure of copper bindingsite in C-terminal of human prion and its comparison with rabbit prion
文献类型：期刊论文
| 作者 | Cui PX(崔培昕); Lian FL(练富林); Wang Y(王宇); Wen Y(文祎); Chu WS(储旺盛); Lin DH(林东海); Wu ZY(吴自玉) |
| 刊名 | Journal of University of Science and Technology of China
 |
| 出版日期 | 2014 |
| 卷号 | 44期号:6页码:474-478 |
| 关键词 | HuPrP copper XANES MXAN RaPrP MXAN |
| ISSN号 | 0253-2778 |
| 其他题名 | 人朊蛋白C端铜结合位点三维精细结构以及与兔朊蛋白的对比 |
| 文献子类 | Article |
| 英文摘要 | Prion protein is considered to be a copper-related protein,and the copper ion induces the secondary structure changes of prion proteins,making them aggregate and deposit in the central nervous system,and causing transmissible spongiform encephalopathies (TSE).The three-dimensional fine structure of C-terminal high-affinity copper binding site was determined in recombinant human prion 91-231(HuPrP~(91-231)),which lacks the octapeptide repeat region,using X-ray absorption near-edge structure(XANES)combined with the ab initio calculations in the framework of the multiple-scattering theory.Results show that amino acid residues have closer distances from the copper ion compared with those of the rabbit prion.This might be the reason why different species have different immunities to TSE. |
| 资助项目 | Supported by the Knowledge Innovation Program of the Chinese Academy of Sciences[00000000] ; the Key Important Project of the National Natural Science Foundation of China[00000000] ; the National Key Basic Research(973)Program of China[00000000] ; the National Natural Science Foundation of China[00000000] ; the Fundamental Research Funds for the Central Universities[00000000] |
| WOS研究方向 | Optics ; Physics (provided by Clarivate Analytics) |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5188155 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269325]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.University of Science and Technology of China, National Synchrotron Radiation Laboratory, Hefei, Anhui 230029, China.; 2.Shanghai Institute of Material Medica,Chinese Academy of Sciences, Shanghai 201203, China.; 3.Shanghai Synchrotron Radiation Facility,Shanghai Institute of Applied Physics,Chinese Academy of Sciences, Shanghai 201204, China.; 4.College of Chemistry and Chemical Engineering, Xiamen University, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen, Fujian 361005, China. |
| 推荐引用方式 GB/T 7714 | Cui PX,Lian FL,Wang Y,et al. 3Dfine structure of copper bindingsite in C-terminal of human prion and its comparison with rabbit prion[J]. Journal of University of Science and Technology of China,2014,44(6):474-478. |
| APA | 崔培昕.,练富林.,王宇.,文祎.,储旺盛.,...&吴自玉.(2014).3Dfine structure of copper bindingsite in C-terminal of human prion and its comparison with rabbit prion.Journal of University of Science and Technology of China,44(6),474-478. |
| MLA | 崔培昕,et al."3Dfine structure of copper bindingsite in C-terminal of human prion and its comparison with rabbit prion".Journal of University of Science and Technology of China 44.6(2014):474-478. |
入库方式： OAI收割
来源：上海药物研究所
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