In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma
文献类型：期刊论文
| 作者 | Hu Y(胡莹); Yang YF(杨雁芳); Yang WZ(杨文志); Zhang YT(张英涛) |
| 刊名 | Journal of Chinese Pharmaceutical Sciences
 |
| 出版日期 | 2014 |
| 卷号 | 23期号:6页码:385-392 |
| 关键词 | Coptidis Rhizoma Alzheimers disease Amyloid beta AChE BACE1 |
| ISSN号 | 1003-1057 |
| 其他题名 | 中药黄连中小檗碱类主要成分抗阿尔茨海默病的多靶点体外活性研究 |
| 文献子类 | Article |
| 英文摘要 | Coptidis Rhizoma, a well known heat-clearing Chinese Materia Medica, exhibited multi-target anti-Alzheimer effects in vitro through inhibition of Abeta42 aggregation, AChE, and BACE1. Six berberinelike alkaloids were found to be the major active constituents of Coptidis Rhizoma by HPLC analysis along with activity assays. A standard combination of the six major alkaloids was demonstrated to fully reproduce the in vitro effects of Coptidis Rhizoma. Molecular docking studies revealed that berberine-like alkaloids could directly bind at the active sites of Abeta42, AChE, and BACE1 through hydrophobic interactions, aromatic stacking, and electrostatic interactions. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5195458 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269326]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Hu Y,Yang YF,Yang WZ,et al. In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma[J]. Journal of Chinese Pharmaceutical Sciences,2014,23(6):385-392. |
| APA | 胡莹,杨雁芳,杨文志,&张英涛.(2014).In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma.Journal of Chinese Pharmaceutical Sciences,23(6),385-392. |
| MLA | 胡莹,et al."In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma".Journal of Chinese Pharmaceutical Sciences 23.6(2014):385-392. |
入库方式： OAI收割
来源：上海药物研究所
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