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Enhanced Oral Absorption of Teniposide Cationic Nanoemulsions

文献类型：期刊论文

作者Niu Baohua2; Ma Li1; Liu Zeying1; Wang Yixin2; Chen Dawei2
刊名Chinese Journal of Pharmaceuticals
出版日期2013
卷号44期号:8页码:781-785
关键词teniposide self-assembly cationic nanoemulsion oral absorption
ISSN号1001-8255
其他题名阳离子纳米乳提高替尼泊苷口服吸收的研究
文献子类Article
英文摘要The teniposide cationic nanoemulsions(TCN) were prepared by a self-assembly technique with D-alpha-tocopherol polyethylene glycol 1000 succinate(TPGS), 12-hydroxystearic acid-polyethylene glycol copolymer(HS-15), octadecylamine and medium chain triglyceride. The product was nanometer-sized with the mean diameter of(61.94.5) nm and the zeta potential of(+8.383.34)mV. The MTT assay showed that the in vitro antitumor activity of teniposide in A549 cells was significantly increased by TCN. The distributions of teniposide from TCN in the intestinal tract and tissues such as heart, liver, spleen, lung and kidney of mice were obviously enhanced compared with teniposide solution. Moreover, the results of in vivo pharmacokinetic test in rats indicated that the c max and AUC of teniposide from TCN were significantly enhanced. Compared with teniposide solution, the oral bioavailability of TCN was 380%.
资助项目国家重大科学研究计划项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4937182
源URL[http://119.78.100.183/handle/2S10ELR8/269371]  
专题中国科学院上海药物研究所
作者单位1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.;
推荐引用方式
GB/T 7714		 Niu Baohua,Ma Li,Liu Zeying,et al. Enhanced Oral Absorption of Teniposide Cationic Nanoemulsions[J]. Chinese Journal of Pharmaceuticals,2013,44(8):781-785.
APA Niu Baohua,Ma Li,Liu Zeying,Wang Yixin,&Chen Dawei.(2013).Enhanced Oral Absorption of Teniposide Cationic Nanoemulsions.Chinese Journal of Pharmaceuticals,44(8),781-785.
MLA Niu Baohua,et al."Enhanced Oral Absorption of Teniposide Cationic Nanoemulsions".Chinese Journal of Pharmaceuticals 44.8(2013):781-785.

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来源：上海药物研究所

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