Assembly and architecture of the Wnt/beta-catenin signalosome at the membrane
文献类型：期刊论文
| 作者 | DeBruine, Zachary J.1; Xu, H. E.2,3; Melcher, Karsten1 |
| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2017-12 |
| 卷号 | 174期号:24页码:4564-4574 |
| ISSN号 | 0007-1188 |
| DOI | 10.1111/bph.14048 |
| 文献子类 | Review |
| 英文摘要 | Wnt/beta-catenin signalling is initiated by a ternary Wnt-Frizzled (FZD)-LDL receptor-related protein (LRP) 5/6 binding event. The resulting conformational changes in the FZD and LRP5/6 receptors promote the assembly of an intracellular signalosome driven by Dishevelled and Axin co-polymerization. Recent evidence suggests that the FZD receptor and LRP5/6 participate in the assembly of this signalosome by forming regulatory scaffolds for stabilizing Dishevelled and Axin adapters. In this review, we focus on the contributions of Wnts and their receptors in the assembly of the signalosome. We present an emerging model, which unifies Wnt receptor oligomerization with intracellular signalosome formation, and then discuss how FZD receptors might be targeted to either disrupt or enhance their capacity as a dynamic sensor of Wnt binding. |
| WOS关键词 | CYSTEINE-RICH DOMAIN ; FAMILIAL EXUDATIVE VITREORETINOPATHY ; PROTEIN-COUPLED RECEPTORS ; DISHEVELLED DEP DOMAIN ; STRUCTURAL BASIS ; BETA-CATENIN ; FRIZZLED FAMILY ; WNT SIGNALOSOME ; LIGAND-BINDING ; CANONICAL WNT |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000427839000003 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272359]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | DeBruine, Zachary J.; Melcher, Karsten |
| 作者单位 | 1.Van Andel Res Inst, Ctr Canc & Cell Biol, Lab Struct Biol & Biochem, Grand Rapids, MI 49503 USA; 2.Van Andel Res Inst, Lab Struct Sci, Ctr Canc & Cell Biol, Grand Rapids, MI USA; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Mat Med Ctr, Van Andel Res Inst,Key Lab Receptor Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | DeBruine, Zachary J.,Xu, H. E.,Melcher, Karsten. Assembly and architecture of the Wnt/beta-catenin signalosome at the membrane[J]. BRITISH JOURNAL OF PHARMACOLOGY,2017,174(24):4564-4574. |
| APA | DeBruine, Zachary J.,Xu, H. E.,&Melcher, Karsten.(2017).Assembly and architecture of the Wnt/beta-catenin signalosome at the membrane.BRITISH JOURNAL OF PHARMACOLOGY,174(24),4564-4574. |
| MLA | DeBruine, Zachary J.,et al."Assembly and architecture of the Wnt/beta-catenin signalosome at the membrane".BRITISH JOURNAL OF PHARMACOLOGY 174.24(2017):4564-4574. |
入库方式： OAI收割
来源：上海药物研究所
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