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Three novel indole alkaloids from Kopsia officinalis

文献类型：期刊论文

作者Wang, Zhi-Wei1; Shi, Xiao-Jian2; Mu, Yan1; Fang, Lei1; Chen, Yue1; Lin, Yun-Liang1
刊名FITOTERAPIA
出版日期2017-06
卷号119页码:8-11
关键词Kopsia officinalis Indole alkaloid Biosynthetic pathway
ISSN号0367-326X
DOI10.1016/j.fitote.2017.01.017
文献子类Article
英文摘要Three new indole alkaloids, named kopsioffines A-C (1-3), possessing relatively novel ten-membered lactam ring, and one known compound (11,12-demethoxy-16-deoxypauciflorine, 4) were isolated from the leaves and stems of Kopsia officinalis. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of 1 was determined by calculated electronic circular dichroism data. The hypothetical biosynthetic pathway of 1 was postulated. All these isolates were evaluated for their inhibitory effects on alpha-glucosidase. None of them showed activity with IC50 far beyond 50 mu M. (C) 2017 Elsevier B.V. All rights reserved.
WOS关键词YUNNAN KOPSIA ; ARBOREA
资助项目Shandong Provincial Natural Science Foundation[ZR2015YL012] ; Science and Technology Program of Shandong Province[2014GSF118156] ; Shandong Academy of Sciences[2014QN005]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000404307800002
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/272634]  
专题中国科学院上海药物研究所
通讯作者Wang, Zhi-Wei
作者单位1.Shandong Acad Sci, Shandong Key Lab TCM Qual Control Technol, Shandong Anal & Test Ctr, 19 Keyuan St, Jinan 250014, Shandong, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Zhi-Wei,Shi, Xiao-Jian,Mu, Yan,et al. Three novel indole alkaloids from Kopsia officinalis[J]. FITOTERAPIA,2017,119:8-11.
APA Wang, Zhi-Wei,Shi, Xiao-Jian,Mu, Yan,Fang, Lei,Chen, Yue,&Lin, Yun-Liang.(2017).Three novel indole alkaloids from Kopsia officinalis.FITOTERAPIA,119,8-11.
MLA Wang, Zhi-Wei,et al."Three novel indole alkaloids from Kopsia officinalis".FITOTERAPIA 119(2017):8-11.

入库方式： OAI收割

来源：上海药物研究所

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