Prenylated flavonoids from the stems and roots of Tripterygiwn wilfordii
文献类型：期刊论文
| 作者 | Chen, Yang2; Zhao, Jianping3; Qiu, Yixing2; Yuan, Hanwen2; Khan, Shabana I.3; Hussain, Nusrat1,2; Choudhary, M. Iqbal1; Zeng, Feng4; Guo, De-An4 ; Khan, Ikhlas A.3
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017-06 |
| 卷号 | 119页码:64-68 |
| 关键词 | Tripterygium wilfordii Celastraceae Flavanone Antimicrobial Antimalarial NMR |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2017.04.003 |
| 文献子类 | Article |
| 英文摘要 | Phytochemical investigation on the stems and roots of Tripterygium wilfordii led to the isolation and characterization of three new prenylated flavanones, tripteryols A-C (1-3), along with (+/-)-5,4'-dihydroxy2'-methoxy-6',6"-dimethypyraro-(2",3":7,8)-6-methyflavanone (4), and ((2S)-5,7,4'-trihydroxy-2'-methoxy-8,5'di(3-methy1-2-buteny1)-6-methylflavanone (5). Structures of the compounds 1-5 were elucidated using spectroscopic techniques, such as UV, IR, NMR (1D and 2D), and HRESI-MS. Tripteryols B (2) was found active in the antimicrobial assay against Cryptococcus neoformans, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with IC50 values in the range of 2.95-8.59 mu g/mL. Compounds 4 and 5 showed significant antimicrobial activities against C. neoformans, MRSA and Staphylococcus aureus with IC50 values in the range of 1.06-2.60 mu g/mL. Additionally, significant antimalarial activities of tripteryols A-B (1-2) against chloroquine-sensitive D6 and resistant W2 clones of Plasmodium falciparum were observed and none of the compounds 1-5 were cytotoxic to Vero cells. |
| WOS关键词 | C-METHYLATED FLAVONOIDS |
| 资助项目 | National Natural Science Foundation of China[81374062] ; National Natural Science Foundation of China[85673179] ; Hunan Science and Technology Department Funds[2014SK4037] ; Hunan Science and Technology Department Funds[FJ1007] ; United States Department of Agriculture, Discovery & Development of Natural Products for Pharmaceutical & Agricultural Applications[58-6060-6-015] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000404307800011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272636]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan; 2.Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China; 3.Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 USA; 4.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yang,Zhao, Jianping,Qiu, Yixing,et al. Prenylated flavonoids from the stems and roots of Tripterygiwn wilfordii[J]. FITOTERAPIA,2017,119:64-68. |
| APA | Chen, Yang.,Zhao, Jianping.,Qiu, Yixing.,Yuan, Hanwen.,Khan, Shabana I..,...&Wang, Wei.(2017).Prenylated flavonoids from the stems and roots of Tripterygiwn wilfordii.FITOTERAPIA,119,64-68. |
| MLA | Chen, Yang,et al."Prenylated flavonoids from the stems and roots of Tripterygiwn wilfordii".FITOTERAPIA 119(2017):64-68. |
入库方式： OAI收割
来源：上海药物研究所
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