New Acorane-Type Sesquiterpene from Acorus calamus L.
文献类型：期刊论文
| 作者 | Li, Juan3; Zhao, Jianping2; Wang, Wei3; Li, Lin4; Zhang, Lan4; Zhao, Xiao-Fang3; Liu, Qing-Ru3; Liu, Fang3; Yang, Min1; Khan, Ikhlas A.2 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2017-04 |
| 卷号 | 22期号:4 |
| 关键词 | Acorus calamus L. Araceae acorane-type sesquiterpene biosynthetic pathway cell proliferation |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules22040529 |
| 文献子类 | Article |
| 英文摘要 | A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six-or five-membered ring. Moreover, compounds 1 (10 mu M), 2 (5 mu M and 10 mu M) and 3 (10 mu M) showed cell proliferation activity on the SK-N-BE (2) cell line. |
| 资助项目 | Key Laboratory of Neurodegenerative Diseases of the Ministry of Education, Capital Medical University[00000000] ; Administration of Traditional Chinese Medicine of Hunan Province, China[00000000] ; Scientific Research Fund of the Hunan Provincial Education Department, China[15C0114] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000404517800027 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272709]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Shun-Xiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA; 3.Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery TC, Changsha 410208, Hunan, Peoples R China; 4.Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Dis, Beijing 100053, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Juan,Zhao, Jianping,Wang, Wei,et al. New Acorane-Type Sesquiterpene from Acorus calamus L.[J]. MOLECULES,2017,22(4). |
| APA | Li, Juan.,Zhao, Jianping.,Wang, Wei.,Li, Lin.,Zhang, Lan.,...&Li, Shun-Xiang.(2017).New Acorane-Type Sesquiterpene from Acorus calamus L..MOLECULES,22(4). |
| MLA | Li, Juan,et al."New Acorane-Type Sesquiterpene from Acorus calamus L.".MOLECULES 22.4(2017). |
入库方式： OAI收割
来源：上海药物研究所
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