Isolation, structural characterization and neuraminidase inhibitory activities of polyphenolic constituents from Flos caryophylli
文献类型：期刊论文
| 作者 | He, Zining2,4; Lian, Wenwen1,3; Liu, Jiawei2; Zheng, Runsheng2; Xu, Hui2; Du, Guanhua1,3; Liu, Ailin1,3 |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2017-03 |
| 卷号 | 19页码:160-167 |
| 关键词 | A (H1N1) influenza virus Neuraminidase inhibitor Flos caryophylli Rhamnetin-3-O-beta-D-glucuronide-6 ''-methyl ester Rhamnazin-3-O-beta-D-glucuronide-6 ''-methyl ester |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2016.12.031 |
| 文献子类 | Article |
| 英文摘要 | Neuraminidase (NA) is one of the key surface proteins of the influenza virus, which is an important target for anti-influenza therapy. In the present study, bioassay-guided fractionation led to isolation of two new compounds, rhamnetin-3-O-b-D-glucuronide-6"-methyl ester (1) and rhamnazin-3-O-beta-D-glucuronide6"-methyl ester (2), along with seventeen known compounds (3-19), from the MeOH extract of Flos Caryophylli using in vitro NA inhibition assay. These isolated compounds exhibited significantly inhibitory effects on the NA with IC50 values ranging from 8.4 to 94.1 mu M and were found to protect MDCK cells from A (H1N1) influenza infections (EC50 = 1.5-84.7 mu M) with very low cytotoxicity to the host cells (CC50 = 374.3-1266.9 mu M)), with selective index (SI) ranging from 7 to 297. The primary structurerelationships of these isolates were also discussed. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | INFLUENZA-VIRUS NEURAMINIDASE ; HYDROLYZABLE TANNINS ; SIALIDASE INHIBITORS ; DERIVATIVES ; INFECTION ; AROMATICUM ; TYROSINASE ; QUERCETIN ; DRUGS ; LEAF |
| 资助项目 | China National Natural Science Foundation[81373432] ; Guangzhuo Science and Technology Program[2014J4100118] ; National Great Science and Technology Major Projects[2012ZX093010022013HXW-11] ; Beijing Natural Science Foundation[7152103] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000397455800031 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272757]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Jiawei; Liu, Ailin |
| 作者单位 | 1.Chinese Acad Sci, Peking Union Med Coll, Beijing 100050, Peoples R China; 2.Guangzhou Univ Chinese Med, Minist Educ, Res Ctr Med Plant Resource Sci & Engn, Key Lab Chinese Med Resource Lingnan, Guangzhou 510006, Peoples R China; 3.Chinese Acad Sci, Inst Mat Med, Beijing Key Lab Drug Target Res & Drug Screening, Beijing 100050, Peoples R China; 4.Guangzhou Med Univ, Affiliated Hosp 3, Dept Pharm, Guangzhou 510150, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Zining,Lian, Wenwen,Liu, Jiawei,et al. Isolation, structural characterization and neuraminidase inhibitory activities of polyphenolic constituents from Flos caryophylli[J]. PHYTOCHEMISTRY LETTERS,2017,19:160-167. |
| APA | He, Zining.,Lian, Wenwen.,Liu, Jiawei.,Zheng, Runsheng.,Xu, Hui.,...&Liu, Ailin.(2017).Isolation, structural characterization and neuraminidase inhibitory activities of polyphenolic constituents from Flos caryophylli.PHYTOCHEMISTRY LETTERS,19,160-167. |
| MLA | He, Zining,et al."Isolation, structural characterization and neuraminidase inhibitory activities of polyphenolic constituents from Flos caryophylli".PHYTOCHEMISTRY LETTERS 19(2017):160-167. |
入库方式： OAI收割
来源：上海药物研究所
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