Protective effect of Anoectochilus roxburghii polysaccharide against CCl4-induced oxidative liver damage in mice
文献类型：期刊论文
| 作者 | Yang, Zhenguo1,2; Zhang, Xiaohui1; Yang, Lawei1,2; Pan, Qunwen1,2; Li, Juan4; Wu, Yongfu2; Chen, Meizhen1; Cui, Shichao1,3; Yu, Jie1 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2017-03 |
| 卷号 | 96页码:442-450 |
| 关键词 | Anoectochilus roxburghii Polysaccharide Hepatoprotective effects |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2016.12.039 |
| 文献子类 | Article |
| 英文摘要 | This study investigated the isolation and characterization of Anoectochilus roxburghii polysaccharides (ARP), and further evaluated whether ARP possessed hepatoprotective activities against CCl4-induced oxidative liver damage in mice. ARP is comprised of glucose and galactose in a 1.9:1 molar ratio, and the molecular weight is 19.5 kDa. ARP displayed significant scavenging effects against hydroxyl radical, superoxide anion radical, DPPH radical and a strong reducing power. In vivo experiment demonstrated ARP (150 mg/kg) administrated to mice for 7 days prior to carbon tetrachloride treatment, attenuated the elevated expression levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG) in serum and inhibited the formation of hepatic malondialdehyde (MDA). ARP pretreatment also increased antioxidant enzyme activities such as glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) in the liver of CCl4-induced mice. Furthermore, hepatic histopathological changes induced by CCl4 were significantly normalized by ARP pretreatment. These findings demonstrated that ARP possessed hepatoprotective effect against acute CCl4-induced liver damage by reducing lipid oxidation. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS关键词 | NF-KAPPA-B ; CARBON-TETRACHLORIDE ; ANTIOXIDANT ACTIVITY ; COLORIMETRIC METHOD ; AQUEOUS EXTRACT ; IN-VITRO ; FORMOSANUS ; STRESS ; OPTIMIZATION ; INJURY |
| 资助项目 | National Natural Science Foundation of Guangdong, China[S2011030005257] ; Youth Science and Technology Foundation Programs of Guangdong Medical University[XK1418] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000393245700050 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272765]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cui, Shichao; Yu, Jie |
| 作者单位 | 1.Shantou Univ, Dept Biol, Shantou 515063, Guangdong, Peoples R China; 2.Guangdong Med Univ, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China; 3.Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Environm Protect Shantou, Shantou 515000, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhenguo,Zhang, Xiaohui,Yang, Lawei,et al. Protective effect of Anoectochilus roxburghii polysaccharide against CCl4-induced oxidative liver damage in mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,96:442-450. |
| APA | Yang, Zhenguo.,Zhang, Xiaohui.,Yang, Lawei.,Pan, Qunwen.,Li, Juan.,...&Yu, Jie.(2017).Protective effect of Anoectochilus roxburghii polysaccharide against CCl4-induced oxidative liver damage in mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,96,442-450. |
| MLA | Yang, Zhenguo,et al."Protective effect of Anoectochilus roxburghii polysaccharide against CCl4-induced oxidative liver damage in mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 96(2017):442-450. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。