A new synthetic method of natural product trichostatin A
文献类型：期刊论文
| 作者 | Zhao Xi2; Zhang Shi-Lei1,2; Duan Wen-Hu1,2
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2007-12 |
| 卷号 | 27期号:12页码:1509-1515 |
| 关键词 | trichostatin A histone deacetylase inhibitor L-proline synthesis |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | An efficient synthesis of trichostatin A, A potent histone deacetylase inhibitor, was reported. The key point in this new approach lied in the highly stereocontrolled establishment of its chiral center using L-proline-catalyzed aldol reaction between p-nitrobenzaldehyde and propaidehyde. The aldol product was obtained with >99% ee and high de (anti : syn =16 : 1). No racemization was found in the following process and the synthetic trichostatin A was a pure R enantiomer with more than 99% ee. |
| WOS关键词 | HISTONE DEACETYLASE INHIBITORS ; FRIEND LEUKEMIC-CELLS ; POTENT ; DIFFERENTIATION ; ENZYME |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3047138 |
| WOS记录号 | WOS:000251996300007 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273101]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao Xi |
| 作者单位 | 1.E China Univ Sci & Technol, Dept Pharmaceut Sci, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao Xi,Zhang Shi-Lei,Duan Wen-Hu. A new synthetic method of natural product trichostatin A[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2007,27(12):1509-1515. |
| APA | Zhao Xi,Zhang Shi-Lei,&Duan Wen-Hu.(2007).A new synthetic method of natural product trichostatin A.CHINESE JOURNAL OF ORGANIC CHEMISTRY,27(12),1509-1515. |
| MLA | Zhao Xi,et al."A new synthetic method of natural product trichostatin A".CHINESE JOURNAL OF ORGANIC CHEMISTRY 27.12(2007):1509-1515. |
入库方式： OAI收割
来源：上海药物研究所
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