Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells
文献类型：期刊论文
| 作者 | Tan, Qing-Rong; Wang, Xin-Zhao; Wang, Chuan-Yue; Liu, Xiao-Jun; Chen, Yun-Chun; Wang, Huai-Hal; Zhang, Rui-Guo; Zhen, Xue-Chu; Tong, Yao; Zhang, Zhang-Jin |
| 刊名 | EUROPEAN NEUROPSYCHOPHARMACOLOGY
 |
| 出版日期 | 2007-12 |
| 卷号 | 17期号:12页码:768-773 |
| 关键词 | classical and atypical antipsychotics intracellular calcium BDNF STAT-3 c-fos PC12 cells |
| ISSN号 | 0924-977X |
| DOI | 10.1016/j.euroneuro.2007.03.003 |
| 文献子类 | Article |
| 英文摘要 | Although classical and atypical antipsychotics may have different effects against neurotoxicity, the underlying mechanisms remain to be elucidated. In the present study, we compared the atypical agents, risperidone (RIP), otanzapine (OLZ), and quetiapine (QTP), with the classical agent haloperidol (HAL) in reducing cytotoxicity induced by rotenone, a mitochondrial complex I inhibitor, in PC12 cells. We also determined whether there were differential effects of RIP and HAL on the expression of brain-derived neurotrophic factor (BDNF), signal transducers and activators of transcription-3 (STAT-3), and the immediate early gene c-fos, as well as intracellular levels of calcium. Exposure to 6 mu M rotenone for 24 h resulted in a significant decrease in cell viability and apoptotic alteration. The rotenone-induced cytotoxicity was dose-dependently worsened by pretreatment with HAL, but significantly improved by the aforementioned atypical agents at low doses. Real-time PCR analysis revealed that HAL pretreatment significantly increased BDNF mRNA expression but did not alter c-fos and STAT-3 expression compared to rotenone-exposed cells. Unlike HAL, RIP pretreatment produced a significant elevation of all the three substance mRNA expression and the expression intensity was 2.6- to 4.6-fold greater than HAL. Pretreatment with RIP, but not HAL, L also effectively prevented an elevation of intracellular levels of calcium provoked by rotenone. These results suggest that the protective effects of atypical antipsychotics are associated with a greater capacity to enhance pro-cell survival factors, therapeutic biomarker expression, and blockade of calcium influx. This may provide an alternative for explaining therapeutic advantages of atypical agents observed in clinical use. (c) 2007 Elsevier B.V. and ECNP. All rights reserved. |
| WOS关键词 | LONG-TERM TREATMENT ; NEUROTROPHIC FACTORS ; PARKINSONS-DISEASE ; MESSENGER-RNA ; ANIMAL-MODELS ; SCHIZOPHRENIA ; HALOPERIDOL ; CLOZAPINE ; BDNF ; HIPPOCAMPUS |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000251231700004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273102]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tan, Qing-Rong |
| 作者单位 | 1.Capital Univ Med Sci, Beijing Anding Hosp, Lab Clin Psychopharmacol, Beijing 100088, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China 4.Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Qing-Rong,Wang, Xin-Zhao,Wang, Chuan-Yue,et al. Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2007,17(12):768-773. |
| APA | Tan, Qing-Rong.,Wang, Xin-Zhao.,Wang, Chuan-Yue.,Liu, Xiao-Jun.,Chen, Yun-Chun.,...&Zhang, Zhang-Jin.(2007).Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.EUROPEAN NEUROPSYCHOPHARMACOLOGY,17(12),768-773. |
| MLA | Tan, Qing-Rong,et al."Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells".EUROPEAN NEUROPSYCHOPHARMACOLOGY 17.12(2007):768-773. |
入库方式： OAI收割
来源：上海药物研究所
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