Microbial transformation of cephalomannine by Luteibacter sp.
文献类型：期刊论文
| 作者 | Li, Jianhua; Dai, Jungui; Chen, Xiaoguang; Zhu, Ping |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2007-12 |
| 卷号 | 70期号:12页码:1846-1849 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0701531 |
| 文献子类 | Article |
| 英文摘要 | Luteibacter sp., a new bacterium isolated from the soil around a Taxus cuspidata Sieb. et Zucc plant, was studied for its capability to metabolize cephalomannine (1). After preparative fermentation, eight metabolites were obtained and characterized as baccatin III (2), baccatin V (3), 10-deacetylbaccatin III (4), 10-deacetyl-10-oxobaccatin V (5), 7-epicephalomannine (6), 10-deacetylcephalomannine (7), 10-deacetyl-7-epicephalomannine (8), and 3'-N-debenzoyl-3'-N-(2-methylbutyryl)-7-epitaxol (9). Among these metabolites, 9 is a new compound. Epimerization of the 7 beta-OH group and hydrolysis of the C-13 side-chain were the two major reactions in this bioprocess. However, the biotransformation of 7 beta-D-Xylosyl- 10-deacetyltaxol (10) with the same strain yielded a C-13 side-chain eliminated product without epimerization at C-7 (11). Metabolites 5-9 and 11, together with 1 and paclitaxel, were evaluated for their inhibitory activities against five human cancer cell lines (HCT-8, Be-7402, BGC-823, A549, and A2780). All these compounds showed less potent activities than paclitaxel, which is currently used in clinical chemotherapy. |
| WOS关键词 | TAXUS-YUNNANENSIS ; TAXANES ; DITERPENOIDS ; WALLICHIANA ; TAXOL |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000252046700002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273108]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Dai, Jungui |
| 作者单位 | Chinese Acad Sci, Inst Mat Med, Dept Biosynth Nat Prod, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jianhua,Dai, Jungui,Chen, Xiaoguang,et al. Microbial transformation of cephalomannine by Luteibacter sp.[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(12):1846-1849. |
| APA | Li, Jianhua,Dai, Jungui,Chen, Xiaoguang,&Zhu, Ping.(2007).Microbial transformation of cephalomannine by Luteibacter sp..JOURNAL OF NATURAL PRODUCTS,70(12),1846-1849. |
| MLA | Li, Jianhua,et al."Microbial transformation of cephalomannine by Luteibacter sp.".JOURNAL OF NATURAL PRODUCTS 70.12(2007):1846-1849. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。