Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis
文献类型：期刊论文
| 作者 | Wang, Zhaojun; Qiu, Ju; Guo, Taylor B.; Liu, Ailian; Wang, Ying; Li, Yin; Zhang, Jingwu Z. |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2007-11-01 |
| 卷号 | 179期号:9页码:5958-5965 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.179.9.5958 |
| 文献子类 | Article |
| 英文摘要 | Ethyl 2-[4-(12-beta-artemisininoxy)jphenoxylproPionate (SM933) is a novel derivative of artemisinin, an herbal compound approved for the treatment of malaria. In this study, we show that SM933 has unique anti-inflammatory properties through regulation of signaling pathways, leading to amelioration of experimental autoimmune encephalomyelitis. The anti-inflammatory properties of SM933 were characterized by inhibition of encephalitogenic T cell responses that were altered to exhibit a Th2 immune deviation and reduced activity and concentration of NO and inducible NO synthase. The observed effect of SM933 was mediated through regulatory mechanisms involving the NF kappa B and the Rig-G/JAB1 signaling pathways. SM933 was found to inhibit the activity of NF kappa B by up-regulating licB, which accounted for various down-stream anti-inflammatory actions. Furthermore, it up-regulated Rig-G through the action of IFN-alpha and prevented JAB1, a master cell cycle regulator, from entering the nucleus to promote p27 degradation, resulting in down-regulation of CDK2 and cyclin A and cell cycle progression. Regulation of the Rig-G/JAB1 pathway by SM933 led to altered cell cycle activity of encephalitogenic T cells as a result of its selective effect on activated, but not resting, T cells. The study indicates that SM933 is a novel anti-inflammatory agent acting through defined signaling mechanisms and provides regulatory mechanisms required for effective drug targeting in treatment of autoinunune disease and inflammation. |
| WOS关键词 | NF-KAPPA-B ; MYELIN BASIC-PROTEIN ; MULTIPLE-SCLEROSIS ; T-CELLS ; MEDIATED APOPTOSIS ; GLATIRAMER ACETATE ; NITRIC-OXIDE ; INHIBITION ; SYSTEM ; MICE |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000250388000040 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273125]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jingwu Z. |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Biol Sci, Shanghai Inst Immunol,Inst Hlth Sci,Joint Immunol, Shanghai, Peoples R China 3.Shanghai Univ E Inst, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhaojun,Qiu, Ju,Guo, Taylor B.,et al. Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis[J]. JOURNAL OF IMMUNOLOGY,2007,179(9):5958-5965. |
| APA | Wang, Zhaojun.,Qiu, Ju.,Guo, Taylor B..,Liu, Ailian.,Wang, Ying.,...&Zhang, Jingwu Z..(2007).Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis.JOURNAL OF IMMUNOLOGY,179(9),5958-5965. |
| MLA | Wang, Zhaojun,et al."Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis".JOURNAL OF IMMUNOLOGY 179.9(2007):5958-5965. |
入库方式： OAI收割
来源：上海药物研究所
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