中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods

文献类型:期刊论文

作者Pu, Jian-Xin; Huang, Sheng-Xiong; Ren, Jie; Xiao, Wei-Lie; Li, Li-Mei; Li, Rong-Tao; Li, Liang-Bo; Liao, Tou-Gen; Lou, Li-Guang; Zhu, Hua-Jie
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2007-11
卷号70期号:11页码:1706-1711
ISSN号0163-3864
DOI10.1021/np070247a
文献子类Article
英文摘要Four new triterpenoids, kadlongilactones C-F (2-5), containing a consecutive hexacyclic [7,7,5,6,6,6] ring system, were isolated from the leaves and stems of Kadsura longipedunculata. In comparison with the NMR data of kadlongilactones A (1) and D (3), a significant phenomena was discovered that ring D of 3 inverted from a half-chair in 1 to a half-boat conformation when the HO-16 group changed from alpha- to beta-orientation. The structures of 2-5 were established on the basis of detailed spectroscopic analysis, and DFT computational methods were applied in the structural validation of compounds 3 and 5. Compounds 1-4 showed significant cytotoxicity against A549, HT-29, and K562 cell lines with IC50 values of 0.49-3.61 mu M in vitro.
WOS关键词ANTI-HIV ACTIVITY ; SCHISANDRA-LANCIFOLIA ; COMPLETE PREDICTION ; ORGANIC-MOLECULES ; UNIQUE SKELETON ; NORTRITERPENOIDS ; TRITERPENE
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000251179000004
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/273126]  
专题中国科学院上海药物研究所
通讯作者Zhu, Hua-Jie
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Beijing 200332, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式
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Pu, Jian-Xin,Huang, Sheng-Xiong,Ren, Jie,et al. Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(11):1706-1711.
APA Pu, Jian-Xin.,Huang, Sheng-Xiong.,Ren, Jie.,Xiao, Wei-Lie.,Li, Li-Mei.,...&Sun, Han-Dong.(2007).Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods.JOURNAL OF NATURAL PRODUCTS,70(11),1706-1711.
MLA Pu, Jian-Xin,et al."Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods".JOURNAL OF NATURAL PRODUCTS 70.11(2007):1706-1711.

入库方式: OAI收割

来源:上海药物研究所

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