Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway
文献类型：期刊论文
| 作者 | Yang, Yun-Bo; Yang, Yi-Xin; Su, Bo; Tang, Yun-Lian; Zhu, Bing-Yang; Hu, Zhuo-Wei; Li, Gui-Yuan; Li, Yuan-Jian; Liao, Duan-Fang |
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2007-09-10 |
| 卷号 | 570期号:1-3页码:125-134 |
| ISSN号 | 0014-2999 |
| 关键词 | Probucol vascular remodeling ERK1/2 VSMC |
| DOI | 10.1016/j.ejphar.2007.05.050 |
| 文献子类 | Article |
| 英文摘要 | Although probucol is known to prevent restenosis by regulating vascular remodeling after percutancous transluminal coronary angioplasty, the mechanisms remain unclear. The present study was designed to investigate whether probucol mediates vascular remodeling via the extracellular signal-regulated kinase 1/2 (ERK1/2) signalling pathway. A rabbit restenosis model was used, in which the New Zealand white rabbits received angioplasty with a 3.5 F angioplasty balloon catheter and the proliferation and migration of smooth muscle cells (SMCs) was induced by oxidized low-density lipoprotein (ox-LDL). We evaluated several vascular remodeling parameters and found that probucol prevented lumen restenosis and mediated expansive remodeling with a remodeling index greater than I and that the proliferation and migration of SMCs was inhibited. Based on Western blot analyses, probucol decreased the expression of phospho-mitogen-activated protein kinase kinases 1 (p-MEK1) and phospho-ERK1/2 and enhanced the expression of mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) and caveolin-1. Cells treated with the MEK1 inhibitor PD98059 demonstrated a remarkable suppression of the effects of probucol. Furthermore, immuno fluorescence analysis showed that probucol inhibited the activation of ERK1/2 by preventing its translocation to the nucleus. It was also found that c-myc expression in aortic tissue after angioplasty and the activator protein 1 (AP1) activity in SMCs induced by ox-LDL were decreased with probucol treatment. In conclusion, probucol mediated vascular remodeling to prevent restenosis after angioplasty by down-regulating the ERK1/2 signaling pathway. (c) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | SERIAL INTRAVASCULAR ULTRASOUND ; LOW-DENSITY-LIPOPROTEIN ; SMOOTH-MUSCLE-CELLS ; NITRIC-OXIDE ; CORONARY-ARTERY ; BALLOON ANGIOPLASTY ; MAP KINASE ; RESTENOSIS ; EXPRESSION ; ACTIVATION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000249295100017 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273150]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liao, Duan-Fang |
| 作者单位 | 1.Nanhua Univ, Sch Life Sci & Technol, Inst Pharm & Pharmacol, Div Pharmacoproteom, Hengyang 421001, Peoples R China 2.Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410083, Peoples R China 3.Cent S Univ, Canc Res Inst, Changsha 410083, Peoples R China 4.Chinese Acad Sci, Inst Mat Med, Beijing, Peoples R China 5.Peking Union Med Coll, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yun-Bo,Yang, Yi-Xin,Su, Bo,et al. Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,570(1-3):125-134. |
| APA | Yang, Yun-Bo.,Yang, Yi-Xin.,Su, Bo.,Tang, Yun-Lian.,Zhu, Bing-Yang.,...&Liao, Duan-Fang.(2007).Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway.EUROPEAN JOURNAL OF PHARMACOLOGY,570(1-3),125-134. |
| MLA | Yang, Yun-Bo,et al."Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway".EUROPEAN JOURNAL OF PHARMACOLOGY 570.1-3(2007):125-134. |
入库方式： OAI收割
来源：上海药物研究所
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