中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana

文献类型:期刊论文

作者Ma, Bin; Huang, Hai-hua; Chen, Xiao-yan; Sun, Yu-ming; Lin, Li-hong; Zhong, Da-fang
刊名ACTA PHARMACOLOGICA SINICA
出版日期2007-07
卷号28期号:7页码:1067-1074
关键词metoprolol biotransformation Cun-ninghamella blakesleeana liquid chromatogrphy-tandem mass spectrometry
ISSN号1671-4083
DOI10.1111/j.1745-7254.2007.00567.x
文献子类Article
英文摘要Aim: To investigate the biotransformation of metoprolol, a beta(1)-cardioselective adrenoceptor antagonist, by filamentous fungus, and to compare the parallels between microbial transformation and mammalian metabolism. Methods: Five strains of Cunninghamella (Celegans AS 3.156, Celegans AS 3.2028, C echinulata AS 3.2004, C blakesleeana AS 3.153 and AS 3.910) were screened for the ability to transform metoprolol. The metabolites of metoprolol produced by C blakesleeana AS 3.153 were separated and assayed by liquid chromatography-tandem mass spectrometry (LC/MSn). The major metabolites were isolated by semipreparative HPLC and the structures were identified by a combination of LC/MSn and nuclear magnetic resonance analysis. Results: Metoprolol was transformed to 7 metabolites; 2 were identified as new metabolites and 5 were known metabolites in mammals. Conclusion: The microbial transformation of metoprolol was similar to the metabolism in mammals. The fungi belonging to Cunninghamella species could be used as complementary models for predicting in vivo metabolism and producing quantities of metabolite references for drugs like metoprolol.
WOS关键词PHASE-II METABOLITES ; TRANSFORMATION ; IDENTIFICATION ; PHENANTHRENE ; ELUCIDATION ; ATENOLOL ; ELEGANS
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:3088181
WOS记录号WOS:000247661400020
出版者BLACKWELL PUBLISHING
源URL[http://119.78.100.183/handle/2S10ELR8/273206]  
专题中国科学院上海药物研究所
通讯作者Zhong, Da-fang
作者单位1.Chinese Acad Sci, Ctr Drug Metab & Pharmacokinet Res, Inst Mat Med, Shanghai 201203, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Ma, Bin,Huang, Hai-hua,Chen, Xiao-yan,et al. Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana[J]. ACTA PHARMACOLOGICA SINICA,2007,28(7):1067-1074.
APA Ma, Bin,Huang, Hai-hua,Chen, Xiao-yan,Sun, Yu-ming,Lin, Li-hong,&Zhong, Da-fang.(2007).Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana.ACTA PHARMACOLOGICA SINICA,28(7),1067-1074.
MLA Ma, Bin,et al."Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana".ACTA PHARMACOLOGICA SINICA 28.7(2007):1067-1074.

入库方式: OAI收割

来源:上海药物研究所

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