Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana
文献类型：期刊论文
| 作者 | Ma, Bin; Huang, Hai-hua; Chen, Xiao-yan ; Sun, Yu-ming; Lin, Li-hong; Zhong, Da-fang
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-07 |
| 卷号 | 28期号:7页码:1067-1074 |
| 关键词 | metoprolol biotransformation Cun-ninghamella blakesleeana liquid chromatogrphy-tandem mass spectrometry |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00567.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To investigate the biotransformation of metoprolol, a beta(1)-cardioselective adrenoceptor antagonist, by filamentous fungus, and to compare the parallels between microbial transformation and mammalian metabolism. Methods: Five strains of Cunninghamella (Celegans AS 3.156, Celegans AS 3.2028, C echinulata AS 3.2004, C blakesleeana AS 3.153 and AS 3.910) were screened for the ability to transform metoprolol. The metabolites of metoprolol produced by C blakesleeana AS 3.153 were separated and assayed by liquid chromatography-tandem mass spectrometry (LC/MSn). The major metabolites were isolated by semipreparative HPLC and the structures were identified by a combination of LC/MSn and nuclear magnetic resonance analysis. Results: Metoprolol was transformed to 7 metabolites; 2 were identified as new metabolites and 5 were known metabolites in mammals. Conclusion: The microbial transformation of metoprolol was similar to the metabolism in mammals. The fungi belonging to Cunninghamella species could be used as complementary models for predicting in vivo metabolism and producing quantities of metabolite references for drugs like metoprolol. |
| WOS关键词 | PHASE-II METABOLITES ; TRANSFORMATION ; IDENTIFICATION ; PHENANTHRENE ; ELUCIDATION ; ATENOLOL ; ELEGANS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3088181 |
| WOS记录号 | WOS:000247661400020 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273206]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhong, Da-fang |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Metab & Pharmacokinet Res, Inst Mat Med, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Bin,Huang, Hai-hua,Chen, Xiao-yan,et al. Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana[J]. ACTA PHARMACOLOGICA SINICA,2007,28(7):1067-1074. |
| APA | Ma, Bin,Huang, Hai-hua,Chen, Xiao-yan,Sun, Yu-ming,Lin, Li-hong,&Zhong, Da-fang.(2007).Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana.ACTA PHARMACOLOGICA SINICA,28(7),1067-1074. |
| MLA | Ma, Bin,et al."Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana".ACTA PHARMACOLOGICA SINICA 28.7(2007):1067-1074. |
入库方式： OAI收割
来源：上海药物研究所
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