New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway
文献类型：期刊论文
| 作者 | Yu, Man-Shan; Wong, Anita Yuk-Yee; So, Kwok-Fai; Fang, Ji-Nian; Yuen, Wai-Hung; Chang, Raymond Chuen-Chung |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2007-06-11 |
| 卷号 | 1153页码:221-230 |
| 关键词 | Nerium indicum neuroprotection polysaccharide beta-amyloid |
| ISSN号 | 0006-8993 |
| DOI | 10.1016/j.brainres.2007.03.074 |
| 文献子类 | Article |
| 英文摘要 | Most of the polysaccharides purified from Chinese medicinal herbs showed anti-tumor and immune-stimulating effects. However, little is known about their effects on neuroprotection. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (A beta) peptides or deprivation of nutrition from serum. In this study, we have isolated and characterized a new polysaccharide from the flowers of N. indicum (named as J6) and aimed to investigate its neuroprotective effects against A[ induced apoptosis. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by A beta peptides in a dose-dependent manner. In contrast to the activation of survival signaling such as Akt found in J2, J3 and J4 fractions, neuroprotective effects of J6 markedly inhibited A beta peptide-stimulated phosphorylation of c-Jun N-terminal kinase (JNK-1) as determined by Western blot analysis. Taken together, the polysaccharide J6 isolated from the flowers of N. indicum can serve as potential neuroprotective agent against neuronal death in Alzheimer's disease and the neuroprotective mechanism may primarily rely on inactivation of JNK signaling pathway. (c) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | AMYLOID PEPTIDE NEUROTOXICITY ; OXIDATIVE STRESS ; LYCIUM-BARBARUM ; PARTIAL NEUROPROTECTION ; ENDOPLASMIC-RETICULUM ; ALZHEIMERS-DISEASE ; BETA-PEPTIDE ; CELL-DEATH ; APOPTOSIS ; INSULIN |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000247423800025 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273228]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yuen, Wai-Hung |
| 作者单位 | 1.Univ Hong Kong, Fac Sci, Dept Chem, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, Inst Mol Technol Drug Discovery & Synth, Open Lab Chem Biol, Hong Kong, Hong Kong, Peoples R China 3.Univ Hong Kong, Dept Anat, Lab Neurodegenerat Dis, Hong Kong, Hong Kong, Peoples R China 4.Univ Hong Kong, Fac Med, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China 5.Univ Hong Kong, Cent Lab, Hong Kong, Hong Kong, Peoples R China 6.Univ Hong Kong, Inst Mol Technol Drug Discovery &Synth, Hong Kong, Hong Kong, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Man-Shan,Wong, Anita Yuk-Yee,So, Kwok-Fai,et al. New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway[J]. BRAIN RESEARCH,2007,1153:221-230. |
| APA | Yu, Man-Shan,Wong, Anita Yuk-Yee,So, Kwok-Fai,Fang, Ji-Nian,Yuen, Wai-Hung,&Chang, Raymond Chuen-Chung.(2007).New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway.BRAIN RESEARCH,1153,221-230. |
| MLA | Yu, Man-Shan,et al."New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway".BRAIN RESEARCH 1153(2007):221-230. |
入库方式： OAI收割
来源：上海药物研究所
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