Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine
文献类型：期刊论文
| 作者 | Jin, Wei; Qu, Le-feng; Chen, Qin; Chang, Xin-zhong; Wu, Jiong; Shao, Zhi-min |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-06 |
| 卷号 | 28期号:6页码:859-868 |
| 关键词 | QGY-7703 cells homoharringtonine apoptosis gene expression |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00569.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To classify the genes responsible for apoptosis in QGY-7703 cells induced by homoharringtonine (HHT). Methods: Apoptosis in QGY-7703 cells induced by HHT was demonstrated by DNA fragmentation and morphological observation. cDNA microarray technology was used to detect gene transcription, and the result of microarrays for genes was confirmed by RT-PCR. Results: Seventy-eight individual mRNA were identified and their transcription levels changed significantly. Those genes, of which 68% were upregulated and 32% were downregulated, were partially related to apoptosis. They were mostly oncogenes, tumor suppressors, enzymes, and kinases. Conclusion: HHT is a potential drug in the treatment of liver cancer. TGF-beta, TNF, FAS, p38 MAP K, and p53 apoptosis signaling pathways were activated during apoptosis in QGY-7703 cells. Such inducible genes may play important roles in apoptosis and deserve to be further studied. |
| WOS关键词 | TRANSCRIPTION FACTOR ; NEURONAL APOPTOSIS ; OXIDATIVE STRESS ; KAPPA-B ; PROTEIN ; OVEREXPRESSION ; IDENTIFICATION ; INHIBITOR ; DEATH ; LOCALIZATION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2845678 |
| WOS记录号 | WOS:000246756300014 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273235]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shao, Zhi-min |
| 作者单位 | 1.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Dept Oncol,Breast Canc Inst,Canc Hosp, Shanghai 200032, Peoples R China 2.Changhai Hosp, Dept Vasc Surg, PLA, Shanghai 200433, Peoples R China 3.Changhai Hosp, Inst Vasc Surg, PLA, Shanghai 200433, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Wei,Qu, Le-feng,Chen, Qin,et al. Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine[J]. ACTA PHARMACOLOGICA SINICA,2007,28(6):859-868. |
| APA | Jin, Wei,Qu, Le-feng,Chen, Qin,Chang, Xin-zhong,Wu, Jiong,&Shao, Zhi-min.(2007).Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine.ACTA PHARMACOLOGICA SINICA,28(6),859-868. |
| MLA | Jin, Wei,et al."Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine".ACTA PHARMACOLOGICA SINICA 28.6(2007):859-868. |
入库方式： OAI收割
来源：上海药物研究所
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