Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis ?
文献类型：期刊论文
| 作者 | Chen, Xiu-Ping; Zhang, Tian-Tai; Du, Guan-Hua |
| 刊名 | CARDIOVASCULAR DRUG REVIEWS
 |
| 出版日期 | 2007 |
| 卷号 | 25期号:2页码:146-161 |
| 关键词 | antiatherosclerotic drugs atherosclerosis LOX-1 OX-LDL |
| ISSN号 | 0897-5957 |
| DOI | 10.1111/j.1527-3466.2007.00009.x |
| 文献子类 | Review |
| 英文摘要 | Endothelial activation and dysfunction induced by oxidized modified low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have shown that a new lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) mediates the recognition and internalization of ox-LDL. LOX-1 is the main receptor for ox-LDL and may play an important role in the pathogenesis of hypertension, diabetes, and, especially, of atherosclerosis. The potential role of LOX-1 in the pathogenesis of atherosclerosis includes: endocytosis of ox-LDL, expression co-location with atherosclerosis enhanced by atherosclerosis-related risk factors, elevated LOX-1 protein in cardiovascular disease, effects related to atherosclerosis and eliminated by antiatherosclerotic drugs. Identification and regulation of LOX-1 and understanding its signal transduction pathways might improve our insight toward the pathogenesis of atherosclerosis and provide a selective treatment approach. LOX-1 might be a potential and promising target for the development of novel antiatherosclerotic drugs. However, due to limited knowledge about LOX-1, there are still many questions to be answered. |
| WOS关键词 | HUMAN CORONARY-ARTERY ; OX-LDL RECEPTOR-1 ; HERITABLE HYPERLIPIDEMIC RABBITS ; VASCULAR ENDOTHELIAL-CELLS ; SMOOTH-MUSCLE-CELLS ; NF-KAPPA-B ; CULTURED BOVINE CHONDROCYTES ; LOX-1 SUPPORTS ADHESION ; LIGAND-BINDING DOMAIN ; TUMOR-NECROSIS-FACTOR |
| WOS研究方向 | Cardiovascular System & Cardiology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000247753700004 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273238]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Du, Guan-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Mat Med, Beijing, Peoples R China 2.Coll Med, Peking Union, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xiu-Ping,Zhang, Tian-Tai,Du, Guan-Hua. Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis ?[J]. CARDIOVASCULAR DRUG REVIEWS,2007,25(2):146-161. |
| APA | Chen, Xiu-Ping,Zhang, Tian-Tai,&Du, Guan-Hua.(2007).Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis ?.CARDIOVASCULAR DRUG REVIEWS,25(2),146-161. |
| MLA | Chen, Xiu-Ping,et al."Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis ?".CARDIOVASCULAR DRUG REVIEWS 25.2(2007):146-161. |
入库方式： OAI收割
来源：上海药物研究所
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