A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity
文献类型：期刊论文
| 作者 | Fan, Damin; Yang, Xiaoliang; Wang, Xiaoyong; Zhang, Shouchun; Mao, Jiafei; Ding, Jian ; Lin, Liping; Guo, Zijian
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| 刊名 | JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
 |
| 出版日期 | 2007-06 |
| 卷号 | 12期号:5页码:655-665 |
| 关键词 | antitumor agent dinuclear platinum complex DNA glutathione guanosine-5 '-monophosphate |
| ISSN号 | 0949-8257 |
| DOI | 10.1007/s00775-007-0214-1 |
| 文献子类 | Article |
| 英文摘要 | Multinuclear Pt(II) complexes represent a novel class of antitumor agents. In this work, a dinuclear monofunctional Pt(II) complex {[cis-Pt(NH3)(2)Cl](2)(4,4'-methylenedianiline)}(NO3)(2) (1) was synthesized and characterized by H-1 NMR, electrospray mass spectrometry, and elemental analysis. The 2D [H-1, N-15] heteronuclear single quantum coherence NMR spectra of N-15-labeled 1 revealed that the cationic core of this water-soluble complex hardly hydrolyzes in aqueous solution and reacts very slowly with glutathione. Hydrolysis appears not to be an essential step for the formation of Pt-guanosine-5'-monophosphate (5'-GMP) or Pt-DNA adducts because the complex can react readily with 5'-GMP and partially transform B-DNA into its Z form. Such properties are desired to achieve the goal of enhancing cytotoxicity and lowering side effects of Pt(II) complexes. In fact, complex 1 is highly cytotoxic against the murine leukemia (P-388) and the human non-small-cell lung cancer (A-549) cell lines, and it is more cytotoxic than cisplatin at most concentrations tested. |
| WOS关键词 | NUCLEAR-MAGNETIC-RESONANCE ; GROUP DOMAIN PROTEINS ; TUMOR-CELL-LINES ; CISPLATIN RESISTANCE ; GEOMETRIC ISOMERISM ; NMR-SPECTROSCOPY ; ANTICANCER DRUGS ; CROSS-LINKS ; CONFORMATIONAL-CHANGES ; NUCLEOTIDE EXCISION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000247482600007 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273241]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Xiaoyong |
| 作者单位 | 1.Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China 2.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China 3.Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Damin,Yang, Xiaoliang,Wang, Xiaoyong,et al. A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2007,12(5):655-665. |
| APA | Fan, Damin.,Yang, Xiaoliang.,Wang, Xiaoyong.,Zhang, Shouchun.,Mao, Jiafei.,...&Guo, Zijian.(2007).A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,12(5),655-665. |
| MLA | Fan, Damin,et al."A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 12.5(2007):655-665. |
入库方式： OAI收割
来源：上海药物研究所
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