Bioactive polyketides from Peperomia duclouxii
文献类型：期刊论文
| 作者 | Li, Na; Wu, Jian-lin; Hasegawa, Toshiaki; Sakai, Jun-ichi; Bai, Li-ming; Wang, Li-yan; Kakuta, Saori; Furuya, Yumiko; Ogura, Hirotsugu; Kataoka, Takao |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2007-06 |
| 卷号 | 70期号:6页码:998-1001 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np070089n |
| 文献子类 | Article |
| 英文摘要 | Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii. The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A and oleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 values that ranged from 4.4 to 9.6 mu g/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calcein accumulation than verapamil at 2.5 and 25 mu g/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderate to weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1 alpha or TNF-alpha. |
| WOS关键词 | DIBENZYLBUTANEDIOL LIGNANS ; DIBENZYLBUTYROLACTONE ; RESISTANCE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000247436000019 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273248]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Na |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Niigata Univ, Dept Chem & Chem Engn, Niigata 9502181, Japan 3.Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan 4.Tokyo Inst Technol, Ctr Biol Resources & Informat, Midori Ku, Yokohama, Kanagawa 2268501, Japan 5.Japanese Fdn Canc Res, Canc Chemotherapy Ctr, Koto Ku, Tokyo 1358550, Japan |
| 推荐引用方式 GB/T 7714 | Li, Na,Wu, Jian-lin,Hasegawa, Toshiaki,et al. Bioactive polyketides from Peperomia duclouxii[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(6):998-1001. |
| APA | Li, Na.,Wu, Jian-lin.,Hasegawa, Toshiaki.,Sakai, Jun-ichi.,Bai, Li-ming.,...&Ando, Masayoshi.(2007).Bioactive polyketides from Peperomia duclouxii.JOURNAL OF NATURAL PRODUCTS,70(6),998-1001. |
| MLA | Li, Na,et al."Bioactive polyketides from Peperomia duclouxii".JOURNAL OF NATURAL PRODUCTS 70.6(2007):998-1001. |
入库方式： OAI收割
来源：上海药物研究所
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