Functional coupling between the prefrontal cortex and dopamine neurons in the ventral tegmental area
文献类型：期刊论文
| 作者 | Gao, Ming; Liu, Chang-Liang; Yang, Shen; Jin, Guo-Zhang ; Bunney, Benjamin S.; Shi, Wei-Xing
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2007-05-16 |
| 卷号 | 27期号:20页码:5414-5421 |
| 关键词 | prefrontal cortex ventral tegmental area dopamine neuron firing pattern slow oscillation bursting |
| ISSN号 | 0270-6474 |
| DOI | 10.1523/JNEUROSCI.5347-06.2007 |
| 文献子类 | Article |
| 英文摘要 | Stimulation of the prefrontal cortex ( PFC) has been shown to have an excitatory influence on dopamine ( DA) neurons. We report here that, under nonstimulated conditions, the activity of DA neurons in the ventral tegmental area ( VTA) also covaries, on a subsecond timescale, with the activity of PFC cells. Thus, in 67% of VTA DA neurons recorded in chloral hydrate-anesthetized rats, the firing of the cell displayed a slow oscillation ( SO) that was highly coherent with the activity of PFC neurons. The SO was suppressed by transections immediately caudal to the PFC or by intra-PFC infusion of tetrodotoxin, suggesting that it depends on inputs derived from the PFC. Unexpectedly, the SO in most VTA DA neurons was reversed in phase relative to PFC cell activity, suggesting that at least part of PFC information is transferred to DA neurons indirectly through inhibitory relay neurons. These results, together with those reported previously, suggest that the PFC can act through multiple pathways to exert both excitatory and inhibitory influences on DA neurons. The observed functional coupling between DA and PFC neurons further suggests that these pathways not only allow a bidirectional control of DA neurons by the PFC, but also enable action potential-dependent DA release to be coordinated, on a subsecond timescale, with glutamate release from PFC terminals. Further understanding of this coordinated activity may provide important new insights into brain functions and disorders thought to involve both VTA DA and PFC neurons. |
| WOS关键词 | SINGLE UNIT-ACTIVITY ; NUCLEUS-ACCUMBENS ; SUBSTANTIA-NIGRA ; IN-VIVO ; ELECTRICAL-STIMULATION ; FRONTAL-CORTEX ; FIRING PATTERN ; CELL ACTIVITY ; D-AMPHETAMINE ; BURST EVENTS |
| 资助项目 | NIDA NIH HHS[DA12944] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000246720600016 |
| 出版者 | SOC NEUROSCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273257]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shi, Wei-Xing |
| 作者单位 | 1.Yale Univ, Sch Med, Neuropsychopharmacol Res Unit, Dept Psychiat, New Haven, CT 06511 USA 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Ming,Liu, Chang-Liang,Yang, Shen,et al. Functional coupling between the prefrontal cortex and dopamine neurons in the ventral tegmental area[J]. JOURNAL OF NEUROSCIENCE,2007,27(20):5414-5421. |
| APA | Gao, Ming,Liu, Chang-Liang,Yang, Shen,Jin, Guo-Zhang,Bunney, Benjamin S.,&Shi, Wei-Xing.(2007).Functional coupling between the prefrontal cortex and dopamine neurons in the ventral tegmental area.JOURNAL OF NEUROSCIENCE,27(20),5414-5421. |
| MLA | Gao, Ming,et al."Functional coupling between the prefrontal cortex and dopamine neurons in the ventral tegmental area".JOURNAL OF NEUROSCIENCE 27.20(2007):5414-5421. |
入库方式： OAI收割
来源：上海药物研究所
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