Preparation and characterization of collagen-modified polylactide microparticles
文献类型：期刊论文
| 作者 | Xiao, Yumei; Xu, Yazhen; Lu, Jian; Zhu, Xiangdong; Fan, Hongsong; Zhang, Xingdong |
| 刊名 | MATERIALS LETTERS
 |
| 出版日期 | 2007-05 |
| 卷号 | 61期号:13页码:2601-2605 |
| 关键词 | microparticles polylactide collagen microspheres surface modification |
| ISSN号 | 0167-577X |
| DOI | 10.1016/j.matlet.2006.10.006 |
| 文献子类 | Article |
| 英文摘要 | To improve cytocompatibility of polylactide (PLA) and to obtain an injectable scaffold for tissue engineering, collagen-modified PLA (CPLA) microparticles were prepared. Poly-(alpha-methacrylic acid)-grafted PLA (PMAA-PLA) was obtained by photooxidization and UV induced polymerization. Suspension of PMAA-PLA microspheres with an average size of 172.8 +/- 3.6 nm was prepared with solvent evaporation technique. CPLA microparticles were prepared by adding collagen acetic acid solution into PMAA-PLA microsphere suspension prepared above. FUR spectrum of PMAA-PLA confirmed that PMAA had been grafted on PLA surface. Analytical results of FTIR, XPS, SEM, hematoxylin and eosin (HE) stained and zeta potential measurement showed that the CPLA microparticles obtained by modifying PMAA-PLA microspheres with collagen molecules uniformly have a microporous structure and a particle size of less than 100 mu m. The CPLA microparticles were expected to be used as an injectable scaffold for tissue regeneration. (C) 2006 Elsevier B.V. All rights reserved. |
| WOS关键词 | LACTIC ACID MEMBRANE ; POLY(L-LACTIC ACID) ; SURFACE ; CYTOCOMPATIBILITY ; IMMOBILIZATION ; SCAFFOLD |
| WOS研究方向 | Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000246407800001 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273276]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fan, Hongsong |
| 作者单位 | 1.Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Yumei,Xu, Yazhen,Lu, Jian,et al. Preparation and characterization of collagen-modified polylactide microparticles[J]. MATERIALS LETTERS,2007,61(13):2601-2605. |
| APA | Xiao, Yumei,Xu, Yazhen,Lu, Jian,Zhu, Xiangdong,Fan, Hongsong,&Zhang, Xingdong.(2007).Preparation and characterization of collagen-modified polylactide microparticles.MATERIALS LETTERS,61(13),2601-2605. |
| MLA | Xiao, Yumei,et al."Preparation and characterization of collagen-modified polylactide microparticles".MATERIALS LETTERS 61.13(2007):2601-2605. |
入库方式： OAI收割
来源：上海药物研究所
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