Spectroscopic studies of aripiprazole
文献类型：期刊论文
| 作者 | Li Jian-feng ; Liu Ai-xiang; Xia Guang-xin; Nian Yi-feng; Shen Jing-shan
|
| 刊名 | SPECTROSCOPY AND SPECTRAL ANALYSIS
 |
| 出版日期 | 2007-05 |
| 卷号 | 27期号:5页码:863-867 |
| 关键词 | aripiprazole ultraviolet spectrum infrared spectrum nuclear magnetic resonance mass spectrum structure identification |
| ISSN号 | 1000-0593 |
| 文献子类 | Article |
| 英文摘要 | The ultraviolet spectrum (UV), infrared spectrum (IR), nuclear magnetic resonance (NMR) and mass spectrum (MS) of aripiprazole, a new antipsychotic drug, were reported and interpreted. The structure of aripiprazole in solution was studied according to the UV spectra detected in solution with different pH values. The vibrations of functional groups of this compound in IR and the isotopic ion peaks in MS were discussed. Moreover, the 2D-NMR techniques, including H-1-H-1 correlation spectroscopy (H-1-H-1 cosy), heteronuclear single-quantum coherence (HSQC), and heteronuclear multiple-bond correlation (HMBC), were used to deduce the structure of this compound. All the H-1 NMR. and C-13 NMR signals were assigned. Especially, the ten different methylenes in this structure were analyzed according to the chemical shifts, coupling constants and correlations in 2D-NMR spectrum. By all these spectral techniques, the structure of aripiprazole was identified. |
| WOS关键词 | SPECTRA |
| WOS研究方向 | Spectroscopy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2867609 |
| WOS记录号 | WOS:000247088600008 |
| 出版者 | BEIJING UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273279]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shen Jing-shan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Jian-feng,Liu Ai-xiang,Xia Guang-xin,et al. Spectroscopic studies of aripiprazole[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2007,27(5):863-867. |
| APA | Li Jian-feng,Liu Ai-xiang,Xia Guang-xin,Nian Yi-feng,&Shen Jing-shan.(2007).Spectroscopic studies of aripiprazole.SPECTROSCOPY AND SPECTRAL ANALYSIS,27(5),863-867. |
| MLA | Li Jian-feng,et al."Spectroscopic studies of aripiprazole".SPECTROSCOPY AND SPECTRAL ANALYSIS 27.5(2007):863-867. |
入库方式： OAI收割
来源：上海药物研究所
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