Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives
文献类型：期刊论文
| 作者 | Ye, Qing-Song; Lou, Li-Guang ; Liu, Wei-Ping; Yu, Yao; Chen, Xi-Zhu; Hou, Shu-Qian; Gao, Wen-Qui; Liu, Yang
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2007-04-15 |
| 卷号 | 17期号:8页码:2146-2149 |
| 关键词 | lipophilic platinum(II) complexes antitumor activity salicylate derivatives |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2007.01.084 |
| 文献子类 | Article |
| 英文摘要 | Novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives as the leaving groups were synthesized and characterized by elemental analysis, FAB(+)-MS, FT-IR, and H-1 NMR spectroscopy. Most of the resulting platinum complexes bad high solubility in organic solvents such as ethanol, acetone, and ether, and had right partition coefficient suited to be encapsulated in liposomes. The pertinent complexes were evaluated for their in vitro cytotoxicity against A549 human lung carcinoma and SGC-7901 human gastric carcinoma cell lines. They showed better cytotoxic activity than carboplatin and oxaliplatin. (c) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CARCINOMA CELL-LINES ; PLATINUM COMPLEXES ; PHASE-I ; DESIGN STRATEGIES ; CISPLATIN ; LIPOSOME ; AGENTS ; PHARMACOKINETICS ; PERSPECTIVES ; LIPOPLATIN |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000246045900006 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273285]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Wei-Ping |
| 作者单位 | 1.Kunming Inst Precious Met, Platinum Based Drug Lab, Kunming 650021, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Qing-Song,Lou, Li-Guang,Liu, Wei-Ping,et al. Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(8):2146-2149. |
| APA | Ye, Qing-Song.,Lou, Li-Guang.,Liu, Wei-Ping.,Yu, Yao.,Chen, Xi-Zhu.,...&Liu, Yang.(2007).Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(8),2146-2149. |
| MLA | Ye, Qing-Song,et al."Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.8(2007):2146-2149. |
入库方式： OAI收割
来源：上海药物研究所
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