Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system
文献类型：期刊论文
| 作者 | Lawson, Brian R.; Manenkova, Yulia; Ahamed, Jasimuddin; Chen, Xiaoru; Zou, Jian-Ping; Baccala, Roberto; Theofilopoulos, Argyrios N.; Yuan, Chong |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2007-04-15 |
| 卷号 | 178期号:8页码:5366-5374 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.178.8.5366 |
| 文献子类 | Article |
| 英文摘要 | Transmethylation affects several cellular events, including T cell activation, and blockade of this pathway may curtail inflammatory/autoimmune responses. Here, we demonstrate that transmethylation inhibition by a novel reversible S-adenosyl-L-homocysteine hydrolase inhibitor leads to immunosuppression by reducing phosphorylation of several key proteins involved in TCR signaling, including Akt, Erk1/2, and NF-kappa B. Remarkably, this effect was largely restricted to CD4 T cells and correlated with reduced arginine methylation of Vav1, an essential guanine nucleotide exchange factor in T cell stimulation. Treatment with the transmethylation inhibitor averted, and even ameliorated, the CD4-mediated autoimmune disease, experimental autoimmune encephalomyelitis. The data suggest that transmethylation is required for CD4 T cell activation, and its inhibition may be a novel approach in the treatment of multiple sclerosis, and other CD4-mediated autoimmune diseases. |
| WOS关键词 | L-HOMOCYSTEINE HYDROLASE ; S-ADENOSYLHOMOCYSTEINE HYDROLASE ; MULTIPLE-SCLEROSIS ; ARGININE METHYLATION ; ENCEPHALOMYELITIS ; RESPONSES ; PROTEIN ; ADENOSYLMETHIONINE ; INACTIVATION ; PATHOGENESIS |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245605300082 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273286]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lawson, Brian R. |
| 作者单位 | 1.Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA 2.Gen Atom Co, Diazyme Labs Div, San Diego, CA 92186 USA 3.Shanghai Inst Materia Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lawson, Brian R.,Manenkova, Yulia,Ahamed, Jasimuddin,et al. Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system[J]. JOURNAL OF IMMUNOLOGY,2007,178(8):5366-5374. |
| APA | Lawson, Brian R..,Manenkova, Yulia.,Ahamed, Jasimuddin.,Chen, Xiaoru.,Zou, Jian-Ping.,...&Yuan, Chong.(2007).Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.JOURNAL OF IMMUNOLOGY,178(8),5366-5374. |
| MLA | Lawson, Brian R.,et al."Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system".JOURNAL OF IMMUNOLOGY 178.8(2007):5366-5374. |
入库方式： OAI收割
来源：上海药物研究所
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