Bioactive lignans from Peperomia duclouxii
文献类型：期刊论文
| 作者 | Li, Na; Wu, Jian-lin; Hasegawa, Toshiaki; Sakai, Jun-ichi; Bai, Li-ming; Wang, Li-yan; Kakuta, Saori; Furuya, Yumiko; Ogura, Hirotsugu; Kataoka, Takao |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2007-04 |
| 卷号 | 70期号:4页码:544-548 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0604533 |
| 文献子类 | Article |
| 英文摘要 | Six new lignans (1-6), along with 14 known compounds, were obtained from Peperomia duclouxii. The new structures were elucidated mainly by the analysis of their NMR and MS data. The absolute configurations of 1-6 were determined by comparing their optical rotations or CD spectra with those of known compounds. In cytotoxic and MDR reversal cell activity assays, compound 3 showed cancer cell growth inhibitory activity against VA-13 and HepG2 cells, with IC50 values of 5.3 and 13.2 mu g/mL, and more potent effects on calcein accumulation in MDR 2780AD cells than verapamil, a positive control. Compound 6 showed anti-inflammatory activity using an ICAM-1 assay (induction of the intercellular adhesion molecule-1), stimulated by IL-1 alpha and TNF-alpha. |
| WOS关键词 | DIBENZYLBUTANEDIOL LIGNANS ; DERIVATIVES ; DIBENZYLBUTYROLACTONE ; RESISTANCE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000246007200009 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273296]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Na |
| 作者单位 | 1.Niigata Univ, Dept Chem & Chem Engn, Niigata 9502181, Japan 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 3.Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan 4.Tokyo Inst Technol, Ctr Biol Resources & Informat, Midori Ku, Yokohama, Kanagawa 2268501, Japan 5.Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Koto Ku, Tokyo 1358550, Japan |
| 推荐引用方式 GB/T 7714 | Li, Na,Wu, Jian-lin,Hasegawa, Toshiaki,et al. Bioactive lignans from Peperomia duclouxii[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(4):544-548. |
| APA | Li, Na.,Wu, Jian-lin.,Hasegawa, Toshiaki.,Sakai, Jun-ichi.,Bai, Li-ming.,...&Ando, Masayoshi.(2007).Bioactive lignans from Peperomia duclouxii.JOURNAL OF NATURAL PRODUCTS,70(4),544-548. |
| MLA | Li, Na,et al."Bioactive lignans from Peperomia duclouxii".JOURNAL OF NATURAL PRODUCTS 70.4(2007):544-548. |
入库方式： OAI收割
来源：上海药物研究所
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