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Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death

文献类型：期刊论文

作者Athanasiou, Andriani; Smith, Paul A.; Vakilpour, Sara; Kumaran, Nethia M.; Turner, Amy E.; Bagiokou, Dimitra; Layfield, Robert; Ray, David E.; Westwell, Andrew D.; Alexander, Stephen P. H.
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2007-03-02
卷号354期号:1页码:50-55
关键词TRPV1 vanilloid capsaicin resiniferatoxin capsazepine SB366791 apoptosis necrosis mitochondria cell death chemotherapy cancer
ISSN号0006-291X
DOI10.1016/j.bbrc.2006.12.179
文献子类Article
英文摘要Time-lapse photomicroscopy of human H460 lung cancer cells demonstrated of the transient receptor potential V1 (TRPV1) channel agonists, (E)-capsaicin and resiniferatoxin, and the TRPV1 antagonists, capsazepine, and SB366791, were able to bring about morphological changes characteristic of apoptosis and/or necrosis. Immunoblot analysis identified immunoreactivity for the transient receptor potential V1 (TRPV1) channel in rat brain samples, but not in rat heart mitochondria or in H460 cells. In isolated rat heart mitochondria, all four ligands caused concentration-dependent decreases in oxygen consumption and mitochondrial membrane potential. (E)Capsaicin and capsazepine evoked concentration-dependent increases and decreases, respectively, in mitochondrial hydrogen peroxide production, whilst resiniferatoxin and SB366791 were without significant effect. These data support the hypothesis that (E)-capsaicin, resiniferatoxin, capsazepine, and SB366791 are all mitochondrial inhibitors, able to activate apoptosis and/or necrosis via non-receptor mediated mechanisms, and also support the use of TRPV1 ligands as anti-cancer agents. (c) 2006 Elsevier Inc. All rights reserved.
WOS关键词PERMEABILITY TRANSITION ; BRAIN MITOCHONDRIA ; CAPSAICIN ; INVOLVEMENT ; ACTIVATION ; APOPTOSIS ; RAT
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000244133800009
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/273308]  
专题中国科学院上海药物研究所
通讯作者Bates, Timothy E.
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Shanghai 201203, Peoples R China
2.Univ Nottingham, Nottingham UK China Collaborat Complementary & Al, Nottingham NG7 2UH, England
3.Univ Nottingham, Sch Community Hlth Sci, Nottingham NG7 2UH, England
4.Univ Nottingham, Sch Biomed Sci, Nottingham NG7 2UH, England
5.Univ Nottingham, MRC Appl Neurosci Grp, Nottingham NG7 2UH, England
6.Univ Cardiff Wales, Welsh Sch Pharm, Cardiff CF10 3XF, Wales
7.Univ Nottingham, Sch Med & Surg Sci, Nottingham NG7 2UH, England
推荐引用方式
GB/T 7714		 Athanasiou, Andriani,Smith, Paul A.,Vakilpour, Sara,et al. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,354(1):50-55.
APA Athanasiou, Andriani.,Smith, Paul A..,Vakilpour, Sara.,Kumaran, Nethia M..,Turner, Amy E..,...&Bates, Timothy E..(2007).Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,354(1),50-55.
MLA Athanasiou, Andriani,et al."Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 354.1(2007):50-55.

入库方式： OAI收割

来源：上海药物研究所

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