Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat
文献类型：期刊论文
| 作者 | Yokoi, Norihide; Hayashi, Chihiro; Fujiwara, Yuuka; Wang, He-Yao ; Seino, Susumu
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| 刊名 | DIABETES
 |
| 出版日期 | 2007-02 |
| 卷号 | 56期号:2页码:506-512 |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/db06-1027 |
| 文献子类 | Article |
| 英文摘要 | The Komeda diabetes-prone (KDP) rat is an animal model of human autoimmune type 1 diabetes. We have previously shown that two major susceptibility genes, the major histocompatibility complex (MHC) RT1(u) haplotype and Cblb (Casitas B-lineage lymphoma b) mutation, are responsible for the development of diabetes in KDP rats, suggesting a two-gene model for development of the disease. To confirm the two-gene model, we produced a congenic strain carrying mutated Cblb alleles of the KDP rat on a non-KDP genetic background harboring the RT1(u) haplotype on its MHC. Despite the low incidence and delayed onset of diabetes, the congenic strain did develop the disease, indicating that type I diabetes can be reconstituted on a non-KDP genetic background with the RT1(u) haplotype and Cblb mutation. Similar to observations in KDP rats, the congenic strain showed insulitis and thyroiditis, symptoms of autoimmunity. The low incidence and delayed onset of the disease strongly suggest involvement of genetic modifiers; the congenic strain established in this study should be useful for the mapping and identification of such modifiers. |
| WOS关键词 | CONGENIC MOUSE STRAINS ; PRONE RAT ; BB RAT ; INBRED STRAIN ; F344 RAT ; CBL-B ; MELLITUS ; LYMPHOPENIA ; IDENTIFICATION ; ESTABLISHMENT |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000243989600028 |
| 出版者 | AMER DIABETES ASSOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273336]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Seino, Susumu |
| 作者单位 | 1.Kobe Univ, Grad Sch Med, Div Cellular & Mol Med, Chuo Ku, Kobe, Hyogo 6500017, Japan 2.Kobe Univ, Grad Sch Med, Clin Genome Informat Ctr, Chuo Ku, Kobe, Hyogo, Japan 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yokoi, Norihide,Hayashi, Chihiro,Fujiwara, Yuuka,et al. Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat[J]. DIABETES,2007,56(2):506-512. |
| APA | Yokoi, Norihide,Hayashi, Chihiro,Fujiwara, Yuuka,Wang, He-Yao,&Seino, Susumu.(2007).Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.DIABETES,56(2),506-512. |
| MLA | Yokoi, Norihide,et al."Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat".DIABETES 56.2(2007):506-512. |
入库方式： OAI收割
来源：上海药物研究所
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