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Promotion of sleep by targeting the orexin system in rats, dogs and humans
文献类型：期刊论文
| 作者 | Brisbare-Roch, Catherine; Dingemanse, Jasper; Koberstein, Ralf; Hoever, Petra; Aissaoui, Hamed; Flores, Susan; Mueller, Celia; Nayler, Oliver; van Gerven, Joop; de Haas, Sanne L. |
| 刊名 | NATURE MEDICINE
 |
| 出版日期 | 2007-02 |
| 卷号 | 13期号:2页码:150-155 |
| ISSN号 | 1078-8956 |
| DOI | 10.1038/nm1544 |
| 文献子类 | Article |
| 英文摘要 | Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in orexinergic function is a pathophysiological hallmark of rodent, canine and human narcolepsy. Here we report that in rats, dogs and humans, somnolence is induced by pharmacological blockade of both orexin OX1 and OX2 receptors. When administered orally during the active period of the circadian cycle, a dual antagonist increased, in rats, electrophysiological indices of both non-REM and, particularly, REM sleep, in contrast to GABA(A) receptor modulators; in dogs, it caused somnolence and increased surrogate markers of REM sleep; and in humans, it caused subjective and objective electrophysiological signs of sleep. No signs of cataplexy were observed, in contrast to the rodent, dog or human narcolepsy syndromes. These results open new perspectives for investigating the role of endogenous orexins in sleep-wake regulation. |
| WOS关键词 | HYPOCRETIN OREXIN ; LOCUS-COERULEUS ; DIURNAL-VARIATION ; LATENCY TEST ; A LEVELS ; NARCOLEPSY ; NEURONS ; WAKEFULNESS ; MICE ; PEPTIDES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000244031700023 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273344]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jenck, Francois |
| 作者单位 | 1.Chinese Acad Sci, Inst Biol Sci, Actel Joint Labs, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Actel Pharmaceut Ltd, Res & Dev, CH-4123 Allschwil, Switzerland 3.Ctr Human Drug Res, NL-2333 CL Leiden, Netherlands |
| 推荐引用方式 GB/T 7714 | Brisbare-Roch, Catherine,Dingemanse, Jasper,Koberstein, Ralf,et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans[J]. NATURE MEDICINE,2007,13(2):150-155. |
| APA | Brisbare-Roch, Catherine.,Dingemanse, Jasper.,Koberstein, Ralf.,Hoever, Petra.,Aissaoui, Hamed.,...&Jenck, Francois.(2007).Promotion of sleep by targeting the orexin system in rats, dogs and humans.NATURE MEDICINE,13(2),150-155. |
| MLA | Brisbare-Roch, Catherine,et al."Promotion of sleep by targeting the orexin system in rats, dogs and humans".NATURE MEDICINE 13.2(2007):150-155. |
入库方式： OAI收割
来源：上海药物研究所
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