The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers
文献类型：期刊论文
| 作者 | Wen, Ai-Dong; Jia, Yan-Yan; Luo, Xiao-Xing; Bi, Lin-Lin; Chen, Xiao-Yan ; Zhong, Da-Fang
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| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2007-01-17 |
| 卷号 | 43期号:2页码:774-778 |
| 关键词 | ropinirole madopar levodopa benserazide pharmacokinetics HPLC/MS/MS |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2006.08.001 |
| 文献子类 | Article |
| 英文摘要 | Ropinirole is a nonergoline dopamine D-2-receptor agonist and has been proven to be effective in both monotherapy and combination therapy for idiopathic Parkinson's disease. The purpose of the present study was to examine the effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers by using liquid chromatography tandem mass spectrometry (HPLC/MS/MS). A single dose of 1 mg ropinirole was given orally after administration of the placebo or Madopar (containing 200 mg levodopa and 50 mg benserazide) to six healthy males and six healthy females in a cross-over randomized study with a minimum washout period of 8 days. Pharmacokinctic parameters were calculated for both treatments. Coadministration of ropinirole and Madopar did not result in a notable change in rate or extent of availability of ropinirole, as shown by the ratios (90% confidence intervals) of 1.045 (0.900, 1.222) for C-max (maximum plasma concentration) and 1.167 (1.086, 1.262) for AUC(0-inf) (the area under the concentration-time curve). Likewise, no significant difference in any of the other pharmacokinetic parameters [T-max (the time needed to reach the C-max), MRT (mean residence time), volume of distribution (V/F), and clearance (CL/F)] was observed between the treatment groups. No clinically relevant adverse effects were detected under either conditions and there are no pharmacokinetic grounds for adjusting the dose of ropinirole when given in combination with Madopar in Chinese patients. (c) 2006 Published by Elsevier B.V. |
| WOS关键词 | PARKINSONS-DISEASE ; LEVODOPA |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000243802700055 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273351]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Ai-Dong |
| 作者单位 | 1.Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China 2.Fourth Mil Med Univ, Dept Pharmacol, Xian 710032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Ai-Dong,Jia, Yan-Yan,Luo, Xiao-Xing,et al. The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,43(2):774-778. |
| APA | Wen, Ai-Dong,Jia, Yan-Yan,Luo, Xiao-Xing,Bi, Lin-Lin,Chen, Xiao-Yan,&Zhong, Da-Fang.(2007).The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,43(2),774-778. |
| MLA | Wen, Ai-Dong,et al."The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 43.2(2007):774-778. |
入库方式： OAI收割
来源：上海药物研究所
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