Effects of pH on DU intake and removal by CBMIDA and EHBP
文献类型：期刊论文
| 作者 | Fukuda, Satoshi; Ikeda, Mizuyo; Nakamura, Mariko; Yan, Xueming; Xie, Yuyuan
|
| 刊名 | HEALTH PHYSICS
 |
| 出版日期 | 2007-01 |
| 卷号 | 92期号:1页码:10-14 |
| 关键词 | actinides chelation uranium, depleted health effects |
| ISSN号 | 0017-9078 |
| DOI | 10.1097/01.HP.0000228931.61447.b3 |
| 文献子类 | Article |
| 英文摘要 | The effects of pH on deleted uranium (DU) and DU removal by chelating agents, catechol-3,6-bis(methyleneiminodiacetic acid) (CBMIDA) and ethane-1-hydroxy1,1-bisphoshonate (EHBP) in rats were examined. Ninety male Wistar rats, 8 wk old, were divided into six groups of 15 rats. Rats of five groups were each preinjected intraperitoneally with 8 mg kg(-1) DU in pH 1, 3, 5, 7, and 10 solutions. In each pH group, rive rats were injected intraperitoneally with 240 mg kg(-1) CBMEDA, and the other five with 10 mg kg(-1) EHBP; the remaining five were used as the corresponding group with no chelating agent. One group was kept as the control (no injected DU) group, which consisted of five intact, five with CBNMA, and five with EHBP administration. Chelating agents were administered for 3 d. Rats were injected with the DU 30 min prior to treatment with chelating agents on the first day. The gathered data indicated that the DU toxicity varied according to differences in pH; in addition, at pH 7, when varied DU-complexes formed, the DU toxicity including renal dysfunction increased, and the DU removal effects of chelating agents were not obtained. Both CBMEDA and EHBP were effective in excreting DU, reducing DU concentrations in organs, and preventing DU-induced toxicity, and CBMIDA was superior to EHBP, particularly in the prevention of renal dysfunction. These results indicate that the excretion and distribution of soluble DU changes and the removal effects of chelating agents according to pH differs, indicating that the treatment with chelating agent should begin in the DU-contaminated person as early as possible after an accident. |
| WOS关键词 | ORAL URANIUM ; COMPLEXES ; EFFICACY ; FLUORIDE ; EXAFS ; RATS |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000242864000002 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273379]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fukuda, Satoshi |
| 作者单位 | 1.Natl Inst Radiol Sci, Res Ctr Radiat Emergency Med, Inage Ku, Chiba 2638555, Japan 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fukuda, Satoshi,Ikeda, Mizuyo,Nakamura, Mariko,et al. Effects of pH on DU intake and removal by CBMIDA and EHBP[J]. HEALTH PHYSICS,2007,92(1):10-14. |
| APA | Fukuda, Satoshi,Ikeda, Mizuyo,Nakamura, Mariko,Yan, Xueming,&Xie, Yuyuan.(2007).Effects of pH on DU intake and removal by CBMIDA and EHBP.HEALTH PHYSICS,92(1),10-14. |
| MLA | Fukuda, Satoshi,et al."Effects of pH on DU intake and removal by CBMIDA and EHBP".HEALTH PHYSICS 92.1(2007):10-14. |
入库方式： OAI收割
来源：上海药物研究所
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