Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPAR gamma ligands (I)
文献类型：期刊论文
| 作者 | Dong, Xiaochun; Zhang, Zhenshan; Wen, Ren; Shen, Jianhua ; Shen, Xu; Jiang, Hualiang
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2006-11-15 |
| 卷号 | 16期号:22页码:5913-5916 |
| 关键词 | de novo drug design PPAR gamma ligand type II diabetes indole compounds |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2006.06.093 |
| 文献子类 | Article |
| 英文摘要 | MCSS and LeapFrog, two de novo drug design programs, were used for the novel indole-based PPAR gamma ligands' study. The designed compounds were synthesized and tested for the PPAR gamma protein binding activities in vitro. Out of the compounds that were synthesized, two molecules (compounds 14d and 7d) possessed potent PPAR gamma protein binding activity close to rosiglitazone in vitro. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ACTIVATED RECEPTOR-GAMMA ; AGONISTS ; BINDING ; SERIES ; AGENTS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000241850400042 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273444]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Ren |
| 作者单位 | 1.Fudan Univ, Dept Med Chem, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Xiaochun,Zhang, Zhenshan,Wen, Ren,et al. Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPAR gamma ligands (I)[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(22):5913-5916. |
| APA | Dong, Xiaochun,Zhang, Zhenshan,Wen, Ren,Shen, Jianhua,Shen, Xu,&Jiang, Hualiang.(2006).Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPAR gamma ligands (I).BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(22),5913-5916. |
| MLA | Dong, Xiaochun,et al."Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPAR gamma ligands (I)".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.22(2006):5913-5916. |
入库方式： OAI收割
来源：上海药物研究所
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