Synthesis and evaluation of 8-[I-131]iodo-substituted imidazopyridine derivative as single photon emission computed tomography tracer for peripheral benzodiazepine receptors
文献类型：期刊论文
| 作者 | Li, Bin; Li, Ran Feng; Sun, Xiao Guang; Huang, Gang |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2006-11 |
| 卷号 | 17期号:11页码:1435-1438 |
| 关键词 | imidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors synthesis iododestannylation |
| ISSN号 | 1001-8417 |
| 文献子类 | Article |
| 英文摘要 | A novel N-methyl, N-phenyl-[6-chloro-2-(4-chlorophenyl)-8-iodoiniidazo[1, 2-a]-pyridine-3-yl]acetamide (compound V) was synthesized, radiolabelled with I-131 and evaluated in vitro. In vitro cell uptake studies showed that MDA-MB-231 cells yield four-fold higher specific uptake of [I-131]-compound VI than MCF-7 cells, corresponding to the increased expression of PBR in MDA-MB-231 cells. Blocking studies significantly reduced the MDA-MB-231 cells uptake of [I-131]-compound VI. It indicated that [I-131]-compound VI might be a potential SPECT radioligand for imaging of PBR. |
| WOS关键词 | IN-VIVO ; BRAIN ; LIGANDS ; DISEASE ; CELLS ; PET |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000243961100005 |
| 出版者 | CHINESE CHEMICAL SOCIETY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273454]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Gang |
| 作者单位 | 1.Jiao Tong Univ, Med Sch Shanghai, Reiji Hosp, Dept Nucl Med, Shanghai 200127, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200127, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bin,Li, Ran Feng,Sun, Xiao Guang,et al. Synthesis and evaluation of 8-[I-131]iodo-substituted imidazopyridine derivative as single photon emission computed tomography tracer for peripheral benzodiazepine receptors[J]. CHINESE CHEMICAL LETTERS,2006,17(11):1435-1438. |
| APA | Li, Bin,Li, Ran Feng,Sun, Xiao Guang,&Huang, Gang.(2006).Synthesis and evaluation of 8-[I-131]iodo-substituted imidazopyridine derivative as single photon emission computed tomography tracer for peripheral benzodiazepine receptors.CHINESE CHEMICAL LETTERS,17(11),1435-1438. |
| MLA | Li, Bin,et al."Synthesis and evaluation of 8-[I-131]iodo-substituted imidazopyridine derivative as single photon emission computed tomography tracer for peripheral benzodiazepine receptors".CHINESE CHEMICAL LETTERS 17.11(2006):1435-1438. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。