A concise and enantioselective approach to the total synthesis of (-)-lasubine I
文献类型：期刊论文
| 作者 | Liu, Shengyang; Fan, Yuping; Peng, Xinxiang; Wang, Wei; Hua, Weiyi; Akber, Haji; Liao, Lixin |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2006-10-30 |
| 卷号 | 47期号:44页码:7681-7684 |
| 关键词 | lasubine ring-closing metathesis Roush allylboration quinolizidine |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2006.08.137 |
| 文献子类 | Article |
| 英文摘要 | An efficient, enantioselective total synthesis of (-)-lasubine I (1) has been achieved in an overall 8.8% yield from readily available starting materials. The important features of this approach include the creation of stereogenic centers through two sequential highly stereoselective Roush allylborations and the use of S(N)2 cyclization and ring-closing metathesis reactions for the construction of the quinolizidine skeleton. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS关键词 | RING-CLOSING METATHESIS ; RUTHENIUM CARBENE COMPLEX ; AMINO BETA-KETOESTERS ; QUINOLIZIDINE ALKALOIDS ; ASYMMETRIC-SYNTHESIS ; OLEFIN METATHESIS ; LASUBINE-II ; STEREOSELECTIVE-SYNTHESIS ; INTRAMOLECULAR ACYLATION ; CONJUGATE ADDITION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000241429400004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273465]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China 3.E China Univ Sci & Technol, Sch Pharm, Dept Med Chem, Shanghai 200237, Peoples R China 4.Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA 5.Chinese Acad Sci, Grad Sch, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shengyang,Fan, Yuping,Peng, Xinxiang,et al. A concise and enantioselective approach to the total synthesis of (-)-lasubine I[J]. TETRAHEDRON LETTERS,2006,47(44):7681-7684. |
| APA | Liu, Shengyang.,Fan, Yuping.,Peng, Xinxiang.,Wang, Wei.,Hua, Weiyi.,...&Liao, Lixin.(2006).A concise and enantioselective approach to the total synthesis of (-)-lasubine I.TETRAHEDRON LETTERS,47(44),7681-7684. |
| MLA | Liu, Shengyang,et al."A concise and enantioselective approach to the total synthesis of (-)-lasubine I".TETRAHEDRON LETTERS 47.44(2006):7681-7684. |
入库方式： OAI收割
来源：上海药物研究所
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