In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum
文献类型：期刊论文
| 作者 | Huang, Fang; Tang, Lin-Hua; Yu, Lin-Qian; Ni, Yi-Chang; Wang, Qin-Mei; Nan, Fa-Jun
|
| 刊名 | BIOMEDICAL AND ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2006-10 |
| 卷号 | 19期号:5页码:367-370 |
| 关键词 | daphnetin antimalarial drug screening |
| ISSN号 | 0895-3988 |
| 文献子类 | Article |
| 英文摘要 | Objective To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Method Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. Results DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro. Conclusion Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds. |
| WOS关键词 | RIBONUCLEOTIDE REDUCTASE ; IRON CHELATORS ; MALARIA ; THERAPY ; AGENTS ; TARGET ; MODE |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2615829 |
| WOS记录号 | WOS:000241586600007 |
| 出版者 | CHINESE ACAD PREVENTIVE MEDICINE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273476]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Fang |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent, Natl Inst Parasite Dis, Shanghai 200025, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Materia Med,Chinese Natl Ctr Drug S, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Fang,Tang, Lin-Hua,Yu, Lin-Qian,et al. In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2006,19(5):367-370. |
| APA | Huang, Fang,Tang, Lin-Hua,Yu, Lin-Qian,Ni, Yi-Chang,Wang, Qin-Mei,&Nan, Fa-Jun.(2006).In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,19(5),367-370. |
| MLA | Huang, Fang,et al."In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 19.5(2006):367-370. |
入库方式： OAI收割
来源：上海药物研究所
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