Effects of (-)stepholidine in animal models for schizophrenia
文献类型：期刊论文
| 作者 | Ellenbroek, Bart A.; Zhang, Xue-xiang; Jin, Guo-zhang
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2006-09 |
| 卷号 | 27期号:9页码:1111-1118 |
| 关键词 | acoustic startle response antipsychotics apomorphine dopamine D-1 receptor dopamine D-2 receptor MK801 paw test prepulse inhibition clozapine haloperidol |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2006.00365.x |
| 文献子类 | Article |
| 英文摘要 | Aim: (-)Stepholidine (SPD) is an active ingredient of the Chinese herb Stephania intermedia, which binds to the dopamine D-1 and D-2 like receptors. Biochemical, electrophysiological and behavioural experiments have provided strong evidence that SPD is both a D-1 and a D-2 antagonist, which could make SPD a unique antipsychotic drug. The present study aimed to investigate the antipsychotic properties of SPD in two animal models for schizophrenia. Methods: The effects of SPD, clozapine and haloperidol in increasing forelimb and hindlimb retraction time in the paw test and in reversing the apornorphine and MK801-induced disruption of prepulse inhibition was investigated. Results: In the paw test, clozapine and SPD increased the hindlimb retraction time, with only a marginal effect on the forelimb retraction time, whereas haloperidol potently increased both. In the prepulse inhibition paradigm, all three drugs reverse the apomorphine-induced disruption in prepulse inhibition, while none of the drugs could reverse the MK801 induced disruption. SPD even slightly, but significantly, potentiated the effects of MK801. Conclusion: The data show that SPD showed antipsychotic-like effects in both the prepulse inhibition paradigm and in the paw test. Moreover, the results of the paw test suggest that SPD has an atypical character with a relatively small potency to induce extrapyramidal side effects. |
| WOS关键词 | PHENCYCLIDINE-INDUCED DISRUPTION ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; PAW TEST ; NEUROLEPTIC DRUGS ; DOPAMINE-RECEPTORS ; PREFRONTAL CORTEX ; ANTIPSYCHOTIC-DRUGS ; FIRING ACTIVITY ; WORKING-MEMORY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2462107 |
| WOS记录号 | WOS:000240554800002 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273497]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ellenbroek, Bart A. |
| 作者单位 | 1.Univ Nijmegen, Mol Neurobiol Sect, Dept Cognit Neurosci, NL-6500 HB Nijmegen, Netherlands 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ellenbroek, Bart A.,Zhang, Xue-xiang,Jin, Guo-zhang. Effects of (-)stepholidine in animal models for schizophrenia[J]. ACTA PHARMACOLOGICA SINICA,2006,27(9):1111-1118. |
| APA | Ellenbroek, Bart A.,Zhang, Xue-xiang,&Jin, Guo-zhang.(2006).Effects of (-)stepholidine in animal models for schizophrenia.ACTA PHARMACOLOGICA SINICA,27(9),1111-1118. |
| MLA | Ellenbroek, Bart A.,et al."Effects of (-)stepholidine in animal models for schizophrenia".ACTA PHARMACOLOGICA SINICA 27.9(2006):1111-1118. |
入库方式： OAI收割
来源：上海药物研究所
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