Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules
文献类型：期刊论文
| 作者 | Gao, Xinliu; Wang, Xiaoyong; Ding, Jian ; Lin, Liping; Li, Yizhi; Guo, Zijian
|
| 刊名 | INORGANIC CHEMISTRY COMMUNICATIONS
 |
| 出版日期 | 2006-07 |
| 卷号 | 9期号:7页码:722-726 |
| 关键词 | platinum antitumor agents drug design structure-activity relationship medicinal chemistry |
| ISSN号 | 1387-7003 |
| DOI | 10.1016/j.inoche.2006.04.011 |
| 文献子类 | Article |
| 英文摘要 | Monofunctional platinum(II) complexes represent a class of antitumor agents that do not obey the classical structure-activity relationships. We report herein two novel platinum(II) complexes [PtL1Cl] (L-1 = L-valine-N-8-quinolylamide) and [PtL2Cl] (L-2 = L-leucine-N-8-quinolylamide) in which Cl- acts as the only potential leaving group. These complexes showed comparable cytotoxicity to cisplatin against the murine leukemia cell line (P-388) and the human non-small-cell lung cancer cell line (A-549), and could potentially form monofunctional adducts with DNA. (C) 2006 Elsevier B.V. All rights reserved. |
| WOS关键词 | DNA-BINDING ; ANTICANCER DRUGS ; CELL-LINES ; CISPLATIN ; AGENTS ; CYTOTOXICITY ; CHEMISTRY ; TOXICITY ; ASSAY ; CIS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000238718300014 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273555]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Xiaoyong |
| 作者单位 | 1.Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 200031, Peoples R China 2.Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China 3.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xinliu,Wang, Xiaoyong,Ding, Jian,et al. Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules[J]. INORGANIC CHEMISTRY COMMUNICATIONS,2006,9(7):722-726. |
| APA | Gao, Xinliu,Wang, Xiaoyong,Ding, Jian,Lin, Liping,Li, Yizhi,&Guo, Zijian.(2006).Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules.INORGANIC CHEMISTRY COMMUNICATIONS,9(7),722-726. |
| MLA | Gao, Xinliu,et al."Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules".INORGANIC CHEMISTRY COMMUNICATIONS 9.7(2006):722-726. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。