Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models
文献类型：期刊论文
| 作者 | Xu, Lin-Feng; Chu, Wen-Jing; Qing, Xiao-Yun; Li, Sheng; Wang, Xue-Song; Qing, Guo-Wei; Fei, Jian; Guo, Li-He |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2006-06 |
| 卷号 | 50期号:8页码:934-940 |
| 关键词 | Dactylicapnos scandens Hutch antidepressant 5-HT (5-hydroxytryptamine, serotonin) noradrenaline (NE) reuptake inhibitor transporter |
| ISSN号 | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2006.01.003 |
| 文献子类 | Article |
| 英文摘要 | The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls. In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR. Protopine at doses of 3.75 mg/kg, 7.5 mg/kg and 30 mg/kg also produces a dose-dependent reduction in immobility in the tail suspension test. The present results open up new possibilities for the use of protopine in the treatment of mood disorders, such as mild and moderate states of depression. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CNS DRUG DISCOVERY ; NEUROTRANSMITTER TRANSPORTERS ; PHARMACOLOGICAL PROFILE ; MONOAMINE TRANSPORTERS ; AFFECTIVE-DISORDERS ; DEPRESSION ; CLONING ; EPIDEMIOLOGY ; EXPRESSION ; DISEASE |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000238825000004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273580]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Li-He |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Model Organism Res Ctr, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 200031, Peoples R China 4.Shanghai Celstar Inst Biotechnol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Lin-Feng,Chu, Wen-Jing,Qing, Xiao-Yun,et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models[J]. NEUROPHARMACOLOGY,2006,50(8):934-940. |
| APA | Xu, Lin-Feng.,Chu, Wen-Jing.,Qing, Xiao-Yun.,Li, Sheng.,Wang, Xue-Song.,...&Guo, Li-He.(2006).Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.NEUROPHARMACOLOGY,50(8),934-940. |
| MLA | Xu, Lin-Feng,et al."Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models".NEUROPHARMACOLOGY 50.8(2006):934-940. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。